- Ceramide-like compounds and a method for preparation thereof, and a cosmetic composition containing the same
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Disclosed herein is a ceramide-like compound having properties of the natural ceramides, and a method for producing the same, and a cosmetic composition containing the same as a active ingredient.
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- Synthesis and radioprotective activity of WR-1065 derivatives: N-(2-acetylthioethyl)-1,3-propanediamine and N,N'-bis(2-acetylthioethyl)-1,3-propanediamine
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N-(2-Acetylthioethyl)-1,3-propanediamine (13a, as its 2HBr salt, or 13b, as its 2CF3CO2H salt) and N,N'-bis(2-acetylthioethyl)-1,3-propanediamine (16, as its 2CF3CO2H salt) have been prepared and evaluated as potential radioprotectors in mice.Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721.Intermediate N-(2-acetylthioethyl)-N,N'-bis(Z or Boc)-1,3-propanediamines were prepared in two ways from the corresponding alcohols.The most convenient method (the Mitsunobu procedure) was used to obtain theN,N'-bis(2-acetylthioethylated) derivative from the corresponding diol.Surprisingly, none of these compounds possesses radioprotective activity. N-(2-acetylthioethyl)-1,3-propanediamine / N,N'-bis(2-acetylthioethyl)-1,3-propanediamine / WR-2721 / WR-1065 / radioprotector
- Oiry, J.,Pue, J. Y.,Laval, J. D.,Fatome, M.,Imbach, J. L.
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- Preparation of a Variety of Macrocyclic Di- and Tetraamides and Their Peraza-Crown Analogs Using the Crab-Like Cyclization Reaction
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Twelve new macrocyclic di- and tetraamides have been synthesized from the reaction of a bis(α-chloroamide) with a primary amine or with a diamine.Some of these cyclic di- and tetraamides contained pendant aminoalkyl groups attached on one or more ring nitrogen atoms.Two macrocyclic dithiadiamides were prepared from the reaction of a bis(α-chloroamide) and a dimercaptan.In every case, 12-, 14- and 15-membered cyclic di- and tetraamides were isolated in good yields.The 9-, 17- and 18-membered macrocycles were prepared in lower yields.Four of the amido-containing macrocycles were reduced by diborane to the peraza-crown compounds.
- Krakowiak, Krzysztof E.,Bradshaw, Jerald S.,Izatt, Reed M.
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p. 1585 - 1589
(2007/10/02)
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