2,2'-(Propane-1,3-diylbis(azanediyl))diethanol

Base Information

• Chemical Name: 2,2'-(Propane-1,3-diylbis(azanediyl))diethanol
• CAS No.: 10563-27-6
• Molecular Formula: C7H18N2O2
• Molecular Weight: 162.232
• Hs Code.: 2922199090
• European Community (EC) Number: 827-003-7
• DSSTox Substance ID: DTXSID60328919
• Wikidata: Q72445973
• Mol file: 10563-27-6.mol

Synonyms:10563-27-6;2,2'-(Propane-1,3-diylbis(azanediyl))diethanol;2-[3-(2-hydroxyethylamino)propylamino]ethanol;N,N'-BIS(2-HYDROXYETHYL)PROPANE-1,3-DIAMINE;2-({3-[(2-hydroxyethyl)amino]propyl}amino)ethan-1-ol;N,N'-Bis(beta-hydroxyethyl)trimethylenediamine Hydrobromide;SCHEMBL2032344;DTXSID60328919;MFCD00045975;AKOS006274581;SB84285;FT-0695140;N,N'-bis(2-hydroxyethyl)-1,3-diaminopropane;EN300-248858;F86450;A895974;2,2'-(Propane-1,3-diyldiazanediyl)di(ethan-1-ol)

Chemical Property of 2,2'-(Propane-1,3-diylbis(azanediyl))diethanol

Chemical Property:

• Boiling Point: 317.6 °C at 760 mmHg
• PKA: 14.49±0.10(Predicted)
• Flash Point: 140 °C
• PSA: 64.52000
• Density: 1.035 g/cm³
• LogP: -0.67790
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 162.136827821
• Heavy Atom Count: 11
• Complexity: 63.5

Purity/Quality:

98% ^*data from raw suppliers

N,N??-Bis(β-hydroxyethyl)trimethylenediamineHBr ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CNCCO)CNCCO

Technology Process of 2,2'-(Propane-1,3-diylbis(azanediyl))diethanol

There total 3 articles about 2,2'-(Propane-1,3-diylbis(azanediyl))diethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethanolamine (141-43-5) + 1,3-dibromo-propane (109-64-8) → N,N'-bis(2-hydroxyethyl)-1,3-propanediamine (10563-27-6)

Guidance literature:

With sodium carbonate; In ethanol; for 16h; Heating;

Reference yield: 20.0%

oxirane (75-21-8,99932-75-9) + Trimethylenediamine (109-76-2,54018-94-9) → 2-[(3-aminopropyl)amino]ethanol (4461-39-6) + N,N'-bis(2-hydroxyethyl)-1,3-propanediamine (10563-27-6)

Guidance literature:

In methanol; at 0 ℃;

DOI:10.1016/0223-5234(96)88208-0

Reference yield:

→ 1,3-bis(N-(2-hydroxyethyl)-palmitoylamino)propane + N,N'-bis(2-hydroxyethyl)-1,3-propanediamine (10563-27-6)

Guidance literature:

upstream raw materials:

ethanolamine

1,3-dibromo-propane

oxirane

Trimethylenediamine

Refernces

• 1、 Oiry, J.,Pue, J. Y.,Laval, J. D.,Fatome, M.,Imbach, J. L.. "Synthesis and radioprotective activity of WR-1065 derivatives: N-(2-acetylthioethyl)-1,3-propanediamine and N,N'-bis(2-acetylthioethyl)-1,3-propanediamine". . p. 47 - 52. Retrieved 2007/10/02.
• 2、 LEE,BERRIDGE Jr.,ROSS,GOODMAN. "SYNTHESIS OF MUSTARDS FROM PUTRESCINE, CADAVERINE, AND". . p. 567 - 569. Retrieved 2007/10/06.