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4-(2-furyl)-4-oxobutanoic acid is a chemical compound with the molecular formula C8H8O4, derived from furan, and is characterized by its potent biological activity. It is recognized for its potential applications in medicine and biotechnology due to its antifungal, antibacterial, and antioxidant properties, as well as its implications in cancer treatment and inflammatory disease management.

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  • 10564-00-8 Structure
  • Basic information

    1. Product Name: 4-(2-furyl)-4-oxobutanoic acid
    2. Synonyms: 4-(2-furyl)-4-oxobutanoic acid
    3. CAS NO:10564-00-8
    4. Molecular Formula: C8H8O4
    5. Molecular Weight: 168.15
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 10564-00-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 363.2°C at 760 mmHg
    3. Flash Point: 173.5°C
    4. Appearance: /
    5. Density: 1.279g/cm3
    6. Vapor Pressure: 6.51E-06mmHg at 25°C
    7. Refractive Index: 1.511
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-(2-furyl)-4-oxobutanoic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(2-furyl)-4-oxobutanoic acid(10564-00-8)
    12. EPA Substance Registry System: 4-(2-furyl)-4-oxobutanoic acid(10564-00-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 10564-00-8(Hazardous Substances Data)

10564-00-8 Usage

Uses

Used in Pharmaceutical Synthesis:
4-(2-furyl)-4-oxobutanoic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with diverse therapeutic effects.
Used in Agrochemical Production:
In the agrochemical industry, 4-(2-furyl)-4-oxobutanoic acid is utilized as a component in the creation of pesticides and other crop protection agents, leveraging its antifungal and antibacterial properties to protect crops from diseases.
Used in Antifungal Applications:
4-(2-furyl)-4-oxobutanoic acid is employed as an antifungal agent for its effectiveness in combating fungal infections, making it a valuable asset in treating a range of fungal-related conditions.
Used in Antibacterial Applications:
4-(2-furyl)-4-oxobutanoic acid is used as an antibacterial agent, harnessing its ability to inhibit bacterial growth, which is crucial in the development of new antibiotics and disinfectants.
Used in Cancer Treatment:
4-(2-furyl)-4-oxobutanoic acid is used as a potential therapeutic agent in oncology, targeting cancer cells and showing promise in the treatment of various types of cancer.
Used in Treatment of Inflammatory Diseases:
Given its potential impact on inflammatory responses, 4-(2-furyl)-4-oxobutanoic acid is used in the management and treatment of inflammatory diseases, helping to reduce inflammation and associated symptoms.
Used in Antioxidant Formulations:
Capitalizing on its antioxidant properties, 4-(2-furyl)-4-oxobutanoic acid is used in the development of antioxidant formulations to combat oxidative stress and related conditions, contributing to overall health and wellness.

Check Digit Verification of cas no

The CAS Registry Mumber 10564-00-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,6 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10564-00:
(7*1)+(6*0)+(5*5)+(4*6)+(3*4)+(2*0)+(1*0)=68
68 % 10 = 8
So 10564-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O4/c9-6(3-4-8(10)11)7-2-1-5-12-7/h1-2,5H,3-4H2,(H,10,11)

10564-00-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(furan-2-yl)-4-oxobutanoic acid

1.2 Other means of identification

Product number -
Other names 4-[2]Furyl-4-oxo-buttersaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10564-00-8 SDS

10564-00-8Downstream Products

10564-00-8Relevant articles and documents

Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

Milanos, Lampros,Brox, Regine,Frank, Theresa,Poklukar, Ga?per,Palmisano, Ralf,Waibel, Reiner,Einsiedel, Jürgen,Dürr, Maximilian,Ivanovi?-Burmazovi?, Ivana,Larsen, Olav,Hjort?, Gertrud Malene,Rosenkilde, Mette Marie,Tschammer, Nuska

, p. 2222 - 2243 (2016)

In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain tetrahydroisoquinoline carboxamide cores. Compound 11 (FAUC1036) is the first strongly biased allosteric agonist of CXCR3 that selectively induces weak chemotaxis and leads to receptor internalization and the β-arrestin 2 recruitment with potency comparable to that of the chemokine CXCL11 without any activation of G proteins. A subtle structural change (addition of a methoxy group, 14 (FAUC1104)) led to a contrasting biased allosteric partial agonist that activated solely G proteins, induced chemotaxis, but failed to induce receptor internalization or β-arrestin 2 recruitment. Concomitant structure-activity relationship studies indicated very steep structure-activity relationships, which steer the ligand bias between the β-arrestin 2 and G protein pathway. Overall, the information presented provides a powerful platform for further development and rational design of strongly biased allosteric agonists of CXCR3.

Acylative Kinetic Resolution of Cyclic Hydroxamic Acids

Yin, Jingwei,Straub, Matthew R.,Liao, Julian D.,Birman, Vladimir B.

supporting information, p. 1546 - 1549 (2022/03/01)

Racemic cyclic hydroxamic acids bearing an aryl substituent adjacent to the hydroxyl group undergo effective acylative kinetic resolution promoted by benzotetramisole (BTM).

AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3

-

Page/Page column 19, (2017/05/02)

The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.

Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed hydrogenation of γ-Ketoamides

Zhao, Mengmeng,Li, Wanfang,Li, Xiaoming,Ren, Kai,Tao, Xiaoming,Xie, Xiaomin,Ayad, Tahar,Ratovelomanana-Vidal, Virginie,Zhang, Zhaowuo

, p. 6164 - 6171 (2014/07/21)

A0series of γ-hydroxy amides were synthesized with high ena~tioselectivities (up to 99%) usyng asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of natu

Chemical and biological studies of nakiterpiosin and nakiterpiosinone

Gao, Shuanhu,Wang, Qiaoling,Huang, Lily Jun-Shen,Lum, Lawrence,Chen, Chuo

supporting information; scheme or table, p. 371 - 383 (2010/03/25)

Nakiterpiosin and nakiterpiosinone are two related C-nor-D-homosteroids isolated from the sponge Terpios hoshinota that show promise as anticancer agents. We have previously described the asymmetric synthesis and revision of the relative configuration of

Compound having effect of promoting neuron differentiation

-

, (2008/06/13)

A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.

The Stereoselective Synthesis of 2-Alkyl γ-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy Esters

Hoffman, Robert V.,Kim, Hwa-Ok

, p. 5107 - 5113 (2007/10/02)

A simple and general protocol for the enentioselective preparation of γ-keto acids and heterocyclic γ-keto acids which have an alkyl group at C-2 is reported.The alkyl group is introduced by chiral alkylation using a scalemic 2-triflyoxy ester.The alkylation takes place with inversion of configuration and is compatible with a variety of alkyl groups.This methodology is thus wellsuited for the preparation of a wide variety of ketomethylene peptide isosteres.

OMEGA-HETEROAROYL(PROPIONYL OR BUTYRYL)-L-PROLINES

-

, (2008/06/13)

This disclosure describes novel substituted ω-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.

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