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TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE is a chemical compound with potential pharmaceutical applications. It is a carboxylate ester derivative of dihydropyrido[4,3-d]pyrimidine, a heterocyclic compound. TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE features a tert-butyl group, a chlorine atom, and a carboxylate group attached to the dihydropyrimidine ring structure, suggesting its potential as a drug candidate or precursor in medicinal chemistry.

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  • TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

    Cas No: 1056934-87-2

  • USD $ 1.9-2.9 / Gram

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  • 1056934-87-2 Structure
  • Basic information

    1. Product Name: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
    2. Synonyms: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE;6-Boc-4-dichloro-5,6,7,8-...;6-Boc-4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine;tert-Butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyriMidin-6(5H)-carboxylate;TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO;tert-butyl 4-chloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;4-Chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid 1,1-dimethylethyl ester;tert-butyl 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate
    3. CAS NO:1056934-87-2
    4. Molecular Formula: C12H16ClN3O2
    5. Molecular Weight: 269.73
    6. EINECS: N/A
    7. Product Categories: pyrimidine;Heterocycle-Pyrimidine series
    8. Mol File: 1056934-87-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE(1056934-87-2)
    11. EPA Substance Registry System: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE(1056934-87-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1056934-87-2(Hazardous Substances Data)

1056934-87-2 Usage

Uses

Since the specific pharmaceutical uses and properties of TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE are not provided in the materials, the following uses are speculative based on its chemical structure and typical applications of similar compounds:
Used in Pharmaceutical Industry:
TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE is used as a potential drug candidate for [specific therapeutic area] due to its unique chemical structure and functional groups that may exhibit biological activity.
Used in Medicinal Chemistry Research:
TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE is used as a precursor in organic synthesis for the development of new pharmaceutical compounds, leveraging its heterocyclic core and functional groups for further chemical modifications.

Check Digit Verification of cas no

The CAS Registry Mumber 1056934-87-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,9,3 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1056934-87:
(9*1)+(8*0)+(7*5)+(6*6)+(5*9)+(4*3)+(3*4)+(2*8)+(1*7)=172
172 % 10 = 2
So 1056934-87-2 is a valid CAS Registry Number.

1056934-87-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1056934-87-2 SDS

1056934-87-2Downstream Products

1056934-87-2Relevant articles and documents

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Meredith, Erik L.,Mainolfi, Nello,Poor, Stephen,Qiu, Yubin,Miranda, Karl,Powers, James,Liu, Donglei,Ma, Fupeng,Solovay, Catherine,Rao, Chang,Johnson, Leland,Ji, Nan,Artman, Gerald,Hardegger, Leo,Hanks, Shawn,Shen, Siyuan,Woolfenden, Amber,Fassbender, Elizabeth,Sivak, Jeremy M.,Zhang, Yiqin,Long, Debby,Cepeda, Rosemarie,Liu, Fang,Hosagrahara, Vinayak P.,Lee, Wendy,Tarsa, Peter,Anderson, Karen,Elliott, Jason,Jaffee, Bruce

, p. 9273 - 9285 (2015/12/23)

The benefit of intravitreal anti-VEGF therapy in treating wet age-related macular degeneration (AMD) is well established. Identification of VEGFR-2 inhibitors with optimal ADME properties for an ocular indication provides opportunities for dosing routes beyond intravitreal injection. We employed a high-throughput in vivo screening strategy with rodent models of choroidal neovascularization and iterative compound design to identify VEGFR-2 inhibitors with potential to benefit wet AMD patients. These compounds demonstrate preferential ocular tissue distribution and efficacy after oral administration while minimizing systemic exposure.

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