TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
• CAS No.: 1056934-87-2
• Molecular Formula: C12H16ClN3O2
• Molecular Weight: 269.731
• Hs Code.: 2933990090

Synonyms:TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE;6-Boc-4-dichloro-5,6,7,8-...;6-Boc-4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine;tert-Butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyriMidin-6(5H)-carboxylate

Chemical Property of TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

Chemical Property:

• PSA: 55.32000
• LogP: 2.36110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-Chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

There total 3 articles about TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H14O3NC6H5 (41276-30-6) → tert-butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (1056934-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / Reflux

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 18 h / 760.05 Torr / Inert atmosphere

3: triphenylphosphine; tetrachloromethane / 1,2-dichloro-ethane / 2.5 h / 70 °C

With tetrachloromethane; palladium 10% on activated carbon; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.5b01227

Reference yield:

C12H17N3O3 → tert-butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (1056934-87-2)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In 1,2-dichloro-ethane; at 70 ℃; for 2.5h;

DOI:10.1021/acs.jmedchem.5b01227

Reference yield:

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (109229-22-3) → tert-butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (1056934-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 18 h / 760.05 Torr / Inert atmosphere

2: triphenylphosphine; tetrachloromethane / 1,2-dichloro-ethane / 2.5 h / 70 °C

With tetrachloromethane; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.5b01227

upstream raw materials:

C₉H₁₄O₃NC₆H₅

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

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