1059172-92-7

Basic information

• Product Name: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
• Synonyms: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
• CAS NO: 1059172-92-7
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.26764
• Mol File: 1059172-92-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate(1059172-92-7)
• EPA Substance Registry System: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate(1059172-92-7)

Safety Data

• Hazardous Substances Data: 1059172-92-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate is used as a key intermediate in organic synthesis for the development of complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the creation of a wide range of compounds with diverse applications.
Used in Drug Discovery:
In the field of drug discovery, tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate is utilized as a starting material or building block for the synthesis of potential pharmaceutical compounds. Its presence in the molecular structure can contribute to the biological activity of the final drug, making it an important component in the development of new therapeutic agents.
Used in Pharmaceutical Compounds Synthesis:
Tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate is used as a crucial component in the synthesis of pharmaceutical compounds. Its unique structure and potential biological activities make it a valuable asset in the creation of new drugs with improved efficacy and selectivity.
Used in Medicinal Chemistry:
In medicinal chemistry, tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate is employed as a versatile building block for the design and synthesis of novel drug candidates. Its unique structural features and potential biological activities contribute to the development of innovative therapeutic agents with improved pharmacological properties.
Overall, tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate is a promising compound with a wide range of applications in various industries, particularly in the fields of organic synthesis, drug discovery, and medicinal chemistry. Its unique structure and potential biological activities make it an invaluable asset in the development of new drugs and therapeutic agents.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109966-30-5 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 
• 147739-88-6 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 

Downstream Products

• 1438073-38-1 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(6-methyloctahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)propoxy)quinazolin-4-amine 
• 1438073-32-5 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(octahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)propoxy)quinazolin-4-amine 
• 1438082-78-0 tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydro-1H-pyrrolo[3,4-b] pyridine-6(2H)-carboxylate 
• 186203-81-6 tert-butyl hexahydro-1H-pyrrolo[3.4-b]pyridine-6(2H)-carboxylate 

Relevant articles and documents

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

CYCLOBUTENEDIONE DERIVATIVES

The present invention relates to compounds of the formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly inflammatory conditions.

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II.