Welcome to LookChem.com Sign In|Join Free

CAS

  • or

106006-85-3

(R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE, commonly known as riluzole, is a pharmaceutical compound with neuroprotective properties. It is primarily used in the treatment of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease also known as Lou Gehrig's disease. Riluzole operates by inhibiting the release of the excitatory neurotransmitter glutamate, which can be toxic to nerve cells in ALS patients. Its neuroprotective effects are believed to help mitigate the damage to these nerve cells, thereby slowing the progression of the disease. It is administered orally, and potential side effects include dizziness, nausea, and weakness. Due to possible interactions with other medications, it is crucial for patients to consult with healthcare providers about their medical history and current medications before starting treatment with riluzole.

106006-85-3 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

  • N-[(6R)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]propanamide

    Cas No: 106006-85-3

  • USD $ 1.9-2.9 / Gram

  • 100 Gram

  • 1000 Metric Ton/Month

  • Chemlyte Solutions
  • Contact Supplier
  • 106006-85-3 Structure

  • Basic information

    1. Product Name: (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE
    2. Synonyms: Propanamide, N-[(6R)-2-amino-4,5,6,7-tetrahydro-6-benzothiazolyl]-;(R)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide
    3. CAS NO:106006-85-3
    4. Molecular Formula: C10H15N3OS
    5. Molecular Weight: 225.31
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 106006-85-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 502.9°Cat760mmHg
    3. Flash Point: 257.9°C
    4. Appearance: /
    5. Density: 1.26g/cm3
    6. Vapor Pressure: 3.06E-10mmHg at 25°C
    7. Refractive Index: 1.596
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 15.52±0.20(Predicted)
    11. CAS DataBase Reference: (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE(106006-85-3)
    13. EPA Substance Registry System: (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE(106006-85-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 106006-85-3(Hazardous Substances Data)

106006-85-3 Usage

Uses

Used in Pharmaceutical Industry:
(R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE is used as a therapeutic agent for the treatment of amyotrophic lateral sclerosis (ALS) due to its ability to inhibit the release of the neurotransmitter glutamate, which is implicated in the damage to nerve cells in ALS patients. Its neuroprotective effects aim to slow the progression of the disease and improve the quality of life for those affected by ALS.

Check Digit Verification of cas no

The CAS Registry Mumber 106006-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,0,0 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 106006-85:
(8*1)+(7*0)+(6*6)+(5*0)+(4*0)+(3*6)+(2*8)+(1*5)=83
83 % 10 = 3
So 106006-85-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N3OS/c1-2-9(14)12-6-3-4-7-8(5-6)15-10(11)13-7/h6H,2-5H2,1H3,(H2,11,13)(H,12,14)/t6-/m1/s1

106006-85-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(6R)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]propanamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106006-85-3 SDS

106006-85-3Relevant articles and documents

PROCESS FOR PREPARING CHIRALLY PURE 2-AMINO-6-(ALKYL)AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES BY LIQUID CHROMATOGRAPHIC RESOLUTION

-

Page/Page column 17-18, (2008/06/13)

Processes for obtaining single enantiomers of 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoles by liquid chromatography are disclosed.

Dopamine autoreceptor agonists: Resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine

Schneider, Claus S.,Mierau, Joachim

, p. 494 - 498 (2007/10/02)

The enantiomers of the aminothiazole analogues of the known dopaminergic agonists apomorphine (1) and 2-aminohydroxytetralin (2) have been prepared. The absolute configurations of the enantiomers of 2,6-diaminotetrahydrobenzothiazole have been established by X-ray crystallographic analysis. Dopamine (DA) autoreceptor agonist activities of the compounds were evaluated. Testing revealed (-)-5, the S enantiomer, to be the most active compound tested (inhibition of GBL accelerated dopamine synthesis and inhibition of α-methyltyrosine-induced decline of DA). In addition (-)-5 does not exhibit stereotyped behavior, suggesting a pronounced selectivity for DA autoreceptors.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 106006-85-3