(R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

Base Information

• Chemical Name: (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE
• CAS No.: 106006-85-3
• Molecular Formula: C10H15 N3 O S
• Molecular Weight: 225.315
• Hs Code.: 2934999090
• Mol file: 106006-85-3.mol

Synonyms:Propanamide,N-(2-amino-4,5,6,7-tetrahydro-6-benzothiazolyl)-, (R)-

Chemical Property of (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 3.06E-10mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 502.9°Cat760mmHg
• PKA: 15.52±0.20(Predicted)
• Flash Point: 257.9°C
• PSA: 96.25000
• Density: 1.26g/cm³
• LogP: 2.08090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE

There total 3 articles about (R)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

propionic acid anhydride (123-62-6) + (R)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine (106092-11-9,104617-49-4) → (+)-2-amino-6-propionamidotetrahydrobenzothiazole (106006-85-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -5 ℃; for 2h;

DOI:10.1021/jm00386a009

Reference yield:

2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole (375824-96-7) → (+)-2-amino-6-propionamidotetrahydrobenzothiazole (106006-85-3) + (S)?2?amino?6?propionamido?4,5,6,7?tetrahydrobenzothiazole (106006-84-2)

Guidance literature:

Purification / work up; Resolution of racemate;

Reference yield:

2,6-diamino-4,5,6,7-tetrahydro-benzthiazole (106006-83-1,104617-49-4) → (+)-2-amino-6-propionamidotetrahydrobenzothiazole (106006-85-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 84 percent / triethylamine / tetrahydrofuran / 2 h / -5 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00386a009

upstream raw materials:

propionic acid anhydride

(R)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine

2,6-diamino-4,5,6,7-tetrahydro-benzthiazole

2-amino-6-(propionylamino)-4,5,6,7-tetrahydrobenzothiazole

Downstream raw materials:

(R)-(+)-pramipexole

(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride

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