10601-98-6

Basic information

• Product Name: Benzene, 1-(chloromethyl)-4-ethynyl-
• Synonyms: 4-ethynyl chloromethylbenzene;4-ethynylbenzyl chloride;p-ethynylbenzyl chloride
• CAS NO: 10601-98-6
• Molecular Formula: C9H7Cl
• Molecular Weight: 150.60500
• Mol File: 10601-98-6.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(chloromethyl)-4-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(chloromethyl)-4-ethynyl-(10601-98-6)
• EPA Substance Registry System: Benzene, 1-(chloromethyl)-4-ethynyl-(10601-98-6)

Safety Data

• Hazardous Substances Data: 10601-98-6(Hazardous Substances Data)

Upstream product

• 10602-04-7 (4-ethynylphenyl)methanol 
• 10602-03-6 ethyl 4-ethynylbenzoate 
• 63697-96-1 4-Ethynylbenzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 275386-60-2 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 933986-40-4 1-(4-ethynylbenzyl)-4-methylpiperazine 
• 1346617-86-4 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine 
• 1346617-87-5 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-phenylpyrimidin-2-amine 

Relevant articles and documents

Ionic-liquid-supported organocatalyst for the enantioselective Michael addition of ketones to nitroolefins

Ionic-liquid-supported triazole-pyrrolidine 2, for the direct asymmetric Michael reaction was successfully synthesized. The supported catalyst demonstrated good activity and high enantioselectivity in the addition of cyclohexanone to nitroolefins. Further

Sensor with a scaffold having changeable conformations

The present invention relates to a scaffolded sensor with a container comprising a drug for triggering drug release, wherein the scaffold is intrinsically conformationally metastable and a method to its manufacture.

Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs

Cancer cells produce elevated levels of reactive oxygen species, which has been used to design cancer specific prodrugs. Their activation relies on at least a bimolecular process, in which a prodrug reacts with ROS. However, at low micromolar concentratio

N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the synthesis of inhibitors of Bcr-Abl

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated invitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the 1,2,3-triazole ring and the amide group. The synthesis involves a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti-(1,4)-triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line. Willing and Abl inhibitors! N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step, with anti-(1,4)-triazole derivatives as the exclusive products. One of these compounds shows general activity similar to that of imatinib, and in particular, it is more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line.

Regio- and stereoselective hydrosilylation of immobilized terminal alkynes

Regio- and stereoselective hydrosilylation of terminal alkynes on solid support using diisopropyl hydrosilanes yielding β-(E)-vinyl silanes with excellent selectivity is reported. The hydrosilylation is catalyzed by Pt(DVDS)/P(iBuNCH2CH2)3N (DVDS = 1,3-divinyl-1,1,3,3-tetramethyl-disiloxane), in which the bulky proazaphosphatrane ligand plays a key role for the selectivity. The immobilized products are characterized with gel phase 13C NMR and 1H high resolution magic angle spinning NMR.