106344-20-1 Usage
Uses
Used in Medical Applications:
Tin mesoporphyrin is used as a treatment for controlling hyperbilirubinemia in preterm and term newborns. It functions as an inhibitor of bilirubin, helping to reduce the levels of this potentially harmful substance in the blood of infants.
Used in Pharmaceutical Research:
In the field of pharmaceutical research, tin mesoporphyrin is utilized as a potent competitive inhibitor of heme oxygenase. This application makes it a valuable compound for studying tumor angiogenesis, particularly in human pancreatic cancer. By inhibiting heme oxygenase, tin mesoporphyrin can provide insights into the underlying mechanisms of cancer progression and potentially contribute to the development of novel therapeutic strategies.
Used in Diagnostic Applications:
Tin mesoporphyrin, under the brand name Stanate (Torcan), is also employed in diagnostic applications. Its ability to inhibit heme oxygenase makes it a useful tool for investigating the role of this enzyme in various pathological conditions, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 106344-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,3,4 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 106344-20:
(8*1)+(7*0)+(6*6)+(5*3)+(4*4)+(3*4)+(2*2)+(1*0)=91
91 % 10 = 1
So 106344-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
106344-20-1Relevant articles and documents
METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS
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Page/Page column 6, (2012/10/08)
Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
