106610-60-0

Basic information

• Product Name: 3'-hydroxy-4'-methoxydiclofenac
• Synonyms: 3'-hydroxy-4'-methoxydiclofenac;[2-(2,6-Dichloro-3-hydroxy-4-methoxyanilino)phenyl]acetic acid;2-(2,6-Dichloro-3-hydroxy-4-methoxyphenylamino)benzeneacetic acid;YALZBLAHGKGDMB-UHFFFAOYSA-N
• CAS NO: 106610-60-0
• Molecular Formula: C₁₅H₁₃Cl₂NO₄
• Molecular Weight: 0
• Mol File: 106610-60-0.mol

Chemical Properties

• Boiling Point: 450.2°Cat760mmHg
• Flash Point: 226.1°C
• Appearance: /
• Density: 1.492g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3'-hydroxy-4'-methoxydiclofenac(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-hydroxy-4'-methoxydiclofenac(106610-60-0)
• EPA Substance Registry System: 3'-hydroxy-4'-methoxydiclofenac(106610-60-0)

Safety Data

• Hazardous Substances Data: 106610-60-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3'-Hydroxy-4'-methoxydiclofenac is used as an active pharmaceutical ingredient for its anti-inflammatory properties. As a derivative of diclofenac, it targets the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body. This makes it a potential candidate for the development of new medications to treat various inflammatory conditions.
Used in Research and Development:
3'-Hydroxy-4'-methoxydiclofenac can be utilized as a research compound in the field of drug discovery and development. Its unique chemical structure and properties may provide insights into the design and synthesis of novel NSAIDs or other therapeutic agents with improved efficacy and reduced side effects.
Used in Analytical Chemistry:
3'-hydroxy-4'-methoxydiclofenac can also be employed as a reference material or standard in analytical chemistry for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or mass spectrometry (MS), for the detection and quantification of diclofenac and its metabolites in biological samples.

Upstream product

• 75117-26-9 N,N-dimethyl-2-(2-vinylphenyl)acetamide 
• 320777-22-8 [2-(3-Benzyloxy-2,6-dichloro-4-methoxy-phenylamino)-phenyl]-acetic acid 

Relevant articles and documents

Synthesis and quantitative structure-activity relationships of diclofenac analogues

The synthesis of a series of 2-anilinophenylacetic acid, close analogues of diclofenac, is described. These compounds were tested in two models used for evaluating the activity of nonsteroidal antiinflammatory drugs (NSAID's), inhibition of cyclooxygenase enzyme activity in vitro, and adjuvant-induced arthritis (AdA) in rats. Statistically significant correlations were found between the inhibitory activities of the compounds in these two models, indicating that cyclooxygenase inhibition seems to be the underlying mechanism for the antiinflammatory activity of these compounds. Quantitative structure-activity relationship (QSAR) analysis revealed that the crucial parameters for activity in both models were the lipophilicity and the angle of twist between the two phenyl rings. Optimal activities were associated with halogen or alkyl substituents in both ortho positions of the anilino ring. Compounds with OH groups in addition to two ortho substituents or compounds with only one or no ortho substituents were less active.