75117-26-9

Basic information

• Product Name: N,N-dimethyl-2-iodophenylacetamide
• Synonyms: 2-(2-iodophenyl)-N,N-dimethylacetamide
• CAS NO: 75117-26-9
• Molecular Formula: C₁₀H₁₂INO
• Molecular Weight: 289.113
• Mol File: 75117-26-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2-iodophenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-iodophenylacetamide(75117-26-9)
• EPA Substance Registry System: N,N-dimethyl-2-iodophenylacetamide(75117-26-9)

Safety Data

• Hazardous Substances Data: 75117-26-9(Hazardous Substances Data)

Upstream product

• 18698-96-9 o-iodophenylacetic acid 
• 506-59-2 N,N-dimethylammonium chloride 
• 7664-93-9 sulfuric acid 
• 76016-34-7 N,N-dimethyl-2-(2-nitro-phenyl)-acetamide 
• 62300-07-6 o-iodophenylacetyl chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 127792-48-7 N,N-dimethyl<2-<(3,5-dichlorophenyl)amino>phenyl>acetamide 
• 698357-36-7 2-[2-(2',6'-dichloro-4'-methoxyphenylamino)phenyl]-N,N-dimethylacetamide 
• 64118-84-9 4'-hydroxydiclofenac 
• 698357-45-8 2-[2-(2',6'-dichloro-4'-hydroxyphenylamino)phenyl]-N,N-dimethylacetamide 
• 127792-30-7 2-[(3,5-dichlorophenyl)amino]phenylacetic acid 
• 127792-34-1 diclofenac 
• 127792-33-0 2-[(3,4-dichlorophenyl)amino]phenylacetic acid 
• 70172-32-6 2-[(2,3-dichlorophenyl)amino]phenylacetic acid 
• 127792-25-0 [2-(2,3,5,6-Tetramethyl-phenylamino)-phenyl]-acetic acid 
• 118423-38-4 2-[(2,6-dichloro-3-methoxy-4-hydroxyphenyl)amino]phenylacetic acid 
• 106610-60-0 3'-Hydroxy-4'-methoxydiclofenac 
• 320777-22-8 [2-(3-Benzyloxy-2,6-dichloro-4-methoxy-phenylamino)-phenyl]-acetic acid 
• 127792-41-0 <2-<2,6-dichloro-3-methoxy-4-(benzyloxy)anilino>phenyl>acetic acid 
• 127792-46-5 Sodium; [2-(2,4-difluoro-phenylamino)-phenyl]-acetate 

Relevant articles and documents

6π/10π-Electrocyclization of ketene-iminium salts for the synthesis of substituted naphthylamines

An intramolecular 6π/10π-electrocyclization from ketene-iminium salts was developed for the preparation of naphthylamines. Various substituents on the nitrogen, on the aromatic ring, and on the olefin were studied. Tricyclic skeletons were obtained in few steps and good overall yields. The electrocyclization of ketene-iminium salts has been computationally explored by means of DFT calculations and their activation barriers were compared to the parent triene as well as the corresponding dienyl allenes and dienyl ketenes. Electrocyclizations for ketene-iminium salts were shown to be highly exergonic and have much smaller barriers to activation.

A novel approach toward the synthesis of strigolactones through intramolecular [2+2] cycloaddition of ketenes and ketene-iminiums to olefins. Application to the asymmetric synthesis of GR-24

An intramolecular [2+2] cycloaddition of ketenes and ketene-iminium was developed for the preparation of GR-24, a synthetic analogue of the family of strigolactone plant hormones. Excellent levels of regioselectivity and of chiral induction were obtained

SUBSTITUTED AMINO PHENYLACETIC ACIDS, DERIVATIVES THEREOF, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS

Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3-C8)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl, bicyclic heterocyclic aryl, (C3-C6)cycloalkylmonocyclic carbocyclic aryl, or (C5 or C6)cycloalkane fused-monocyclic carbocyclic aryl; pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.