3'-Hydroxy-4'-methoxydiclofenac

Base Information

Chemical Name:3'-Hydroxy-4'-methoxydiclofenac
CAS No.:106610-60-0
Molecular Formula:C15H13 Cl2 N O4
Molecular Weight:0
Hs Code.:2922509090
UNII:CY7817W711
DSSTox Substance ID:DTXSID90147675
Nikkaji Number:J341.704B
Wikidata:Q27225705
Metabolomics Workbench ID:66928
ChEMBL ID:CHEMBL1033
Mol file:106610-60-0.mol

Synonyms:3'-hydroxy-4'-methoxydiclofenac

Suppliers and Price of 3'-Hydroxy-4'-methoxydiclofenac

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
3??-Hydroxy-4??-methoxydiclofenac
10 mg
$ 2400.00

Total 3 raw suppliers

Chemical Property of 3'-Hydroxy-4'-methoxydiclofenac

Chemical Property:

Boiling Point:450.2°Cat760mmHg
Flash Point:226.1°C
PSA：78.79000
Density:1.492g/cm³
LogP:4.15130
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:4.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:341.0221633
Heavy Atom Count:22
Complexity:385

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

3??-Hydroxy-4??-methoxydiclofenac ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C(=C1O)Cl)NC2=CC=CC=C2CC(=O)O)Cl
Uses 3''-Hydroxy-4''-methoxydiclofenac is a derivative of Diclofenac (Sodium Salt: D436450). Diclofenac is the first non-steroidal anti-inflammatory drug (NSAID) that is derived from phenylacetic acid. Diclofenac, like other NSAIDs, primarily works by targeting the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body.

Technology Process of 3'-Hydroxy-4'-methoxydiclofenac

There total 4 articles about 3'-Hydroxy-4'-methoxydiclofenac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 320777-22-8
[2-(3-Benzyloxy-2,6-dichloro-4-methoxy-phenylamino)-phenyl]-acetic acid

: 106610-60-0
3'-Hydroxy-4'-methoxydiclofenac

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 0.416667h; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1021/jm00171a008

Reference yield:

: 75117-26-9
N,N-dimethyl-2-(2-vinylphenyl)acetamide

: 106610-60-0
3'-Hydroxy-4'-methoxydiclofenac

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate, copper, cuprous iodide / toluene / 100 h / Heating

2: KOH / ethanol / 10 h / Heating

3: H₂ / 5percent Pd/C / tetrahydrofuran; various solvent(s) / 0.42 h / 760 Torr / Ambient temperature

With potassium hydroxide; copper(l) iodide; hydrogen; copper; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00171a008

Reference yield:

: 3-Benzyloxy-2,6-dichloro-4-methoxy-phenylamine

: 106610-60-0
3'-Hydroxy-4'-methoxydiclofenac

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate, copper, cuprous iodide / toluene / 100 h / Heating

2: KOH / ethanol / 10 h / Heating

3: H₂ / 5percent Pd/C / tetrahydrofuran; various solvent(s) / 0.42 h / 760 Torr / Ambient temperature

With potassium hydroxide; copper(l) iodide; hydrogen; copper; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jm00171a008