106719-08-8Relevant articles and documents
DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS
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Page/Page column 80, (2013/10/22)
Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H- imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES
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Page/Page column 24, (2011/04/14)
The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS
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Page/Page column 32, (2011/09/20)
The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.
PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS
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Page/Page column 88, (2009/04/25)
The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituants are as defined in the claims.
NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES
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Page/Page column 59, (2009/10/22)
The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula I.
GENERATION OF SPECIFICALLY SUBSTITUTED PYRIDINES AND PYRIDONES FROM 2(1H) PYRAZINONES AND ACETYLENES: A FMO DESCRIPTION
Tutonda, M.,Vanderzande, D.,Hendrickx, M.,Hoornaert, G.
, p. 5715 - 5732 (2007/10/02)
The title compounds were obtained from reaction of variously substituted 2(1H)pyrazinones with acetylenic derivatives.Experimental evidence points out to a two step mechanism: a Diels Alder cycloaddition followed by immediate decomposition of the adducts
DIELS-ALDER REACTIONS OF THE HETERODIENE SYSTEM IN 2(1H)-PYRAZINONES
Tutonda, M.,Vanderzande, D.,Vekemans, J.,Toppet, S.,Hoornaert, G.
, p. 2509 - 2512 (2007/10/02)
Variously substituted 2(1H)-pyrazinones react with acetylenic derivatives to give specifically substituted pyridones or pyridines.The observed selectivity can be explained in terms of HO-LU interactions for the reagents and two competitive retro Diels-Ald