105596-63-2

Basic information

• Product Name: 2-Methoxy-4-pyridinecarboxylic acid
• Synonyms: 2-METHOXYISONICOTINIC ACID;2-METHOXYPYRIDINE-4-CARBOXYLIC ACID;2-METHOXY-4-PYRIDINECARBOXYLIC ACID;2-METHOXYISONICOTONIC ACID;4-Pyridinecarboxylicacid,2-methoxy-(9CI);4-METHOXY-4-PYRIDINECARBOXYLIC ACID;Zinc00336011;2-methoxy-4-picolinic acid
• CAS NO: 105596-63-2
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Product Categories: CARBOXYLICACID;blocks;Carboxes;Pyridines;Pyridine
• Mol File: 105596-63-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 197-200°C
• Boiling Point: 383 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: White to pale brown/Solid or Crystalline Powder
• Density: 1.284 g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.50±0.10(Predicted)
• CAS DataBase Reference: 2-Methoxy-4-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-pyridinecarboxylic acid(105596-63-2)
• EPA Substance Registry System: 2-Methoxy-4-pyridinecarboxylic acid(105596-63-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 105596-63-2(Hazardous Substances Data)

Usage

General Description

2-Methoxy-4-pyridinecarboxylic acid, also known as 2-Methoxyisonicotinic acid, is a chemical compound with the molecular formula C8H7NO4. It is a derivative of pyridinecarboxylic acid and contains a methoxy group attached to the second carbon of the pyridine ring. 2-Methoxy-4-pyridinecarboxylic acid is typically used in the pharmaceutical industry as a building block for the synthesis of various medications, particularly those with antiviral and antitumor properties. It has also been studied for its potential anti-inflammatory and antioxidant effects. 2-Methoxy-4-pyridinecarboxylic acid is considered to be a valuable intermediate in organic synthesis due to its versatile reactivity and potential for biological activity.

InChI:InChI=1/C7H7NO3/c1-11-6-4-5(7(9)10)2-3-8-6/h2-4H,1H3,(H,9,10)/p-1

Upstream product

• 15855-06-8 2-chloro-6-methoxy-isonicotinic acid 
• 26156-51-4 methyl 2-methoxyisonicotinate 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 66080-45-3 2-methoxypyridin-4-ol 
• 124-38-9 carbon dioxide 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 106719-08-8 Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate 
• 42521-10-8 2-chloro-6-methoxyisonicotinic acid methyl ester 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 

Downstream Products

• 764708-20-5 1-(2-methoxypyridin-4-yl)ethanone 
• 1187669-32-4 2-bromo-1-(2-methoxypyridin-4-yl)ethanone 
• 72716-87-1 2-methoxypyridine-4-carboxaldehyde 
• 120277-15-8 4-(bromomethyl)-2-methoxypyridine 
• 123148-66-3 2-methoxy-4-(hydroxymethyl)-pyridine 
• 355013-79-5 4-(chloromethyl)-2-methoxypyridine 
• 1380672-90-1 N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]-2-methoxy-pyridine-4-carbohydrazide 
• 1380672-01-4 4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyridine 
• 1380672-00-3 4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine 
• 1312559-09-3 (S)-2-methoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide 
• 193538-79-3 2-methoxypyridine-4-carbonyl chloride 
• 126798-21-8 2-methoxy-N-phenylisonicotinamide 

Relevant articles and documents

Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections

Conjugating a siderophore to an antibiotic is a promising strategy to overcome the permeability-mediated resistance of Gram-negative pathogens. On the basis of the structure of BAL30072, novel pyridone-conjugated monosulfactams incorporating diverse substituents into the methylene linker between the 1,3-dihydroxypyridin-4(1H)-one and the aminothiazole oxime were designed and synthesized. Structure-activity relationship studies revealed that a variety of substituents were tolerated, with isopropyl (compound 12c) and methylthiomethyl (compound 16a) showing the best efficacy against multidrug-resistant (MDR) Gram-negative pathogens. In addition, compound 12c exhibits a good free fraction rate in an in vitro human plasma protein binding test, along with a low clearance and favorable plasma exposure in vivo. In a murine systemic infection model with MDR Klebsiella pneumoniae, compound 12c shows an ED50 of 10.20 mg/kg. Taken together, the results indicate that compound 12c is a promising drug candidate for the treatment of serious infections caused by MDR Gram-negative pathogens.

NEW 2-AMIDOTHIADIAZOLE DERIVATIVES

New 2-amidothiadiazole derivatives having the chemical structure of formula (I) or pharmaceutically acceptable salts or N-oxides thereof as agonists of S1P1 receptors.