106727-54-2

Basic information

• Product Name: 2(1H)-Pyridinone, 3-acetyl-4-hydroxy- (9CI)
• Synonyms: 2(1H)-Pyridinone, 3-acetyl-4-hydroxy- (9CI);3-Acetyl-1,2-dihydro-4-hydroxypyridin-2-one;3-Acetyl-4-hydroxypyridin-2(1H)-one
• CAS NO: 106727-54-2
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.13538
• Product Categories: ACETYLGROUP
• Mol File: 106727-54-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyridinone, 3-acetyl-4-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 3-acetyl-4-hydroxy- (9CI)(106727-54-2)
• EPA Substance Registry System: 2(1H)-Pyridinone, 3-acetyl-4-hydroxy- (9CI)(106727-54-2)

Safety Data

• Hazardous Substances Data: 106727-54-2(Hazardous Substances Data)

Usage

Derivative of pyridinone

This indicates that the compound is derived from pyridinone, a chemical structure that is the basis for many biologically active compounds.

Contains an acetyl group

The presence of an acetyl group (-COCH3) on the third position of the pyridinone ring gives the compound additional reactivity and allows for further chemical modification.

Contains a hydroxy group

The presence of a hydroxy group (-OH) on the fourth position of the pyridinone ring provides opportunities for hydrogen bonding and other interactions with other molecules.

Building block in organic synthesis and pharmaceutical research

The compound is commonly used as a starting material in the synthesis of more complex molecules, including drugs and other biologically active compounds.

Valuable intermediate

The compound is a valuable intermediate in the production of various compounds due to its reactivity and structure.

Opportunities for modifying properties

The structure of the compound provides opportunities for modifying its properties and enhancing its potential uses in various industries.

Upstream product

• 106727-53-1 3-(1-iminoethyl)-4-hydroxy-2-pyridone 
• 106727-59-7 3-{1-[(E)-Benzylimino]-ethyl}-4-hydroxy-1H-pyridin-2-one 
• 505031-91-4 (E)-5-Benzyloxycarbonylamino-3-pyrrolidin-1-yl-pent-2-enoic acid ethyl ester 
• 164223-36-3 Ethyl 5-(2-benzyloxycarbonylaminoethyl)-3-methylisoxazole-4-carboxylate 
• 164223-35-2 ethyl 5-{[(benzyloxy)carbonyl]amino}-3-oxopentanoate 
• 164223-41-0 3-Methyl-7-phenylseleno-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one 
• 164223-42-1 3-Methyl-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one 
• 164223-43-2 3-Methyl-4,5-dihydroisoxazolo<4,5-c>pyridin-4-one 
• 229308-48-9 3-(2-benzyloxycarbonylaminoethyl)isoxazole-4-carboxylate 
• 229308-47-8 3-methyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 229308-50-3 N-chloro-3-methyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-one 
• 229308-51-4 3-methyl-4,5-dihydroisoxazolo[4,3-c]pyridin-4-one 
• 229308-55-8 3-acetyl-4-amino-1H-pyridin-2-one 

Relevant articles and documents

A second-generation cycloaddition approach to 3-acyl-4-hydroxypyridin- 2-ones

The 1,3-dipolar cycloaddition of the β-aminonitrile oxide, formed from β-alanine, to the enamine of a β-ketoester affords a 3-(2- aminoalkyl)isoxazole-4-carboxylic ester that is converted via isoxazolo[4,5- c]pyridin-4-ones into 3-acetyl-4-hydroxypyridin-2-ones.

1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones

1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.

SYNTHESIS OF 1,3-DIOXIN-4-ONES AND THEIR USE IN SYNTHESIS. XI. 2,2-DIMETHYL-1,3-DIOXIN-4-ONE AS A SYNTHETIC EQUIVALENT OF FORMYLKETENE: SYNTHESIS OF HETEROCYCLIC COMPOUNS

Cycloaddition of formylketene generated in situ by thermolysis of 2,2-dimethyl-1,3-dioxin-4-one with N-benzhydrylidenebenzylamine yields 3-benzyl-2,2-diphenyl-1,3-oxazin-4-one.Analogous reactions with a carbodiimide, cyanamide, and keteneacetal afford the corresponding 4 + 2 cycloadducts.Reaction of formylketene with 3-amino-2-butenamides affords 4-hydroxy-2-pyridones having a C-2 unit at the 3-position.Keywords: 1,3-dioxin-4-one;formylketene; cycloaddition;1,3-oxazin-4-one; 4-pyrone; 3-acetyl-4-hydroxy-2-pyridone; thermolysis; uracil derivative.