Aqueous-mediated ring opening of epoxides with oximes: A rapid entry into β-hydroxy oxime O-ethers as potential β-adrenergic blocking agents
Novel β-hydroxy oxime O-ethers, as potential β-adrener-gic blocking agents, were synthesized from the aqueous-mediated (H2O - DMSO, 7:3) O-alkylation of oximes with epoxides in the presence of potassium hydroxide at room temperature. The O-alkylation was regioselective and (E)-oxime ethers were the main products. The results of quantum mechanical studies used to rationalize the experimental outcomes are discussed. Thieme Stuttgart.
Rad, Mohammad Navid Soltani,Behrouz, Somayeh,Dianat, Manije
experimental part
p. 2055 - 2064
(2009/04/03)
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