1068001-09-1Relevant articles and documents
Aqueous-mediated ring opening of epoxides with oximes: A rapid entry into β-hydroxy oxime O-ethers as potential β-adrenergic blocking agents
Rad, Mohammad Navid Soltani,Behrouz, Somayeh,Dianat, Manije
experimental part, p. 2055 - 2064 (2009/04/03)
Novel β-hydroxy oxime O-ethers, as potential β-adrener-gic blocking agents, were synthesized from the aqueous-mediated (H2O - DMSO, 7:3) O-alkylation of oximes with epoxides in the presence of potassium hydroxide at room temperature. The O-alkylation was regioselective and (E)-oxime ethers were the main products. The results of quantum mechanical studies used to rationalize the experimental outcomes are discussed. Thieme Stuttgart.