1073266-02-0

Basic information

• Product Name: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE
• Synonyms: (1R,4R)-4-(Trifluoromethyl)cyclohexan-1-amine;Cyclohexanamine, 4-(trifluoromethyl)-;TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE;trans-4-Trifluoromethyl-cyclohexylamine;TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXAN-1-AMINE
• CAS NO: 1073266-02-0
• Molecular Formula: C₇H₁₂F₃N
• Molecular Weight: 167.1720896
• Mol File: 1073266-02-0.mol

Chemical Properties

• Boiling Point: 145.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• Refractive Index: 1.4040 to 1.4080
• PKA: 10.29±0.70(Predicted)
• CAS DataBase Reference: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE(1073266-02-0)
• EPA Substance Registry System: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE(1073266-02-0)

Safety Data

• RIDADR: UN 2734 8/3/PG II
• HazardClass: 8/3
• PackingGroup: II
• Hazardous Substances Data: 1073266-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the development of new medications.
Used in Agrochemical Industry:
In agrochemicals, TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE is utilized as a component in the creation of compounds that help protect crops and enhance agricultural productivity.
Used in Specialty Chemicals Production:
TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE is employed in the production of specialty chemicals, where its unique properties are leveraged to create high-value products for specific applications.
Used as a Reagent in Organic Synthesis:
TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE is used as a reagent in organic synthesis, facilitating various chemical reactions that are crucial in the preparation of complex organic molecules.
Used as a Precursor for Fluorinated Compounds:
It serves as a precursor in the preparation of fluorinated compounds, which are important in a range of applications due to the unique properties conferred by fluorine atoms.

Upstream product

• 1087351-23-2 benzyl-(4-trifluoromethylcyclohexyl)amine 
• 75092-01-2 4-trifluoromethylcyclohexanone oxime 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 455-14-1 4-trifluoromethylphenylamine 

Downstream Products

• 1360622-19-0 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(difluoromethoxy)-1H-benzimidazole-5-carboxylic acid amide 
• 1380648-47-4 N-(trans-4-trifluoromethyl-cyclohexyl)-6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid amide 
• 1360624-52-7 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(difluoromethoxy)-5-amino-4-nitro-benzoic acid amide 

Relevant articles and documents

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

Aliphatic C-H Bond Oxidation with Hydrogen Peroxide Catalyzed by Manganese Complexes: Directing Selectivity through Torsional Effects

Substituted N-cyclohexyl amides undergo aliphatic C-H bond oxidation with H2O2 catalyzed by manganese complexes. The reactions are directed by torsional effects leading to site-selective oxidation of cis-1,4-, trans-1,3-, and cis-1,2-cyclohexanediamides. The corresponding diastereoisomers are unreactive under the same conditions. Competitive oxidation of cis-trans mixtures of 4-substituted N-cyclohexylamides leads to quantitative conversion of the cis-isomers, allowing isolation and successive conversion of the trans-isomers into densely functionalized oxidation products with excellent site selectivity and good enantioselectivity.

PYRROLO[2,3-C]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE

Disclosed are a pyrrolo[2,3-c]pyridine derivative, a preparation method therefor, and use thereof in medicine. Specifically, disclosed are a pyrrolo[2,3-c]pyridine derivative as represented by general formula (1), a preparation method therefor, a pharmaceutical composition comprising the derivative, as well as use thereof as a BRD4 inhibitor in the treatment of related diseases such as cancers, inflammations, chronic liver diseases, diabetes, cardiovascular diseases and AIDS, each substituent in general formula (I) being same as defined in the description.

An improved synthesis of 2-, 3-, and 4-(trifluoromethyl)cyclohexylamines

An improved synthesis of 2-, 3-, and 4-trifluoromethylcyclohexylamines on a multigram scale via PtO2-mediated hydrogenation of the corresponding trifluoromethylanilines in trifluoroacetic acid at room temperature under atmospheric pressure is reported. The hydrogenation occurred with a remarkable stereoselectivity favoring the formation of cis-isomers. Georg Thieme Verlag Stuttgart New York.