1074365-84-6

Basic information

• Product Name: Apixaban IMpurity 6
• Synonyms: Apixaban IMpurity 6;1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo- 1-piperidinyl)phenyl]-, Methyl ester;1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate;Apixaban Methyl ester Impurity(BMS-719288-01)
• CAS NO: 1074365-84-6
• Molecular Formula: C₂₆H₂₆N₄O₅
• Molecular Weight: 474.50844
• EINECS: 604-604-1
• Product Categories: API Impurity
• Mol File: 1074365-84-6.mol

Chemical Properties

• Boiling Point: 754.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 0.78±0.20(Predicted)
• CAS DataBase Reference: Apixaban IMpurity 6(CAS DataBase Reference)
• NIST Chemistry Reference: Apixaban IMpurity 6(1074365-84-6)
• EPA Substance Registry System: Apixaban IMpurity 6(1074365-84-6)

Safety Data

• Hazardous Substances Data: 1074365-84-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Apixaban Impurity 6 is used as a reference compound for quality control and analytical purposes in the pharmaceutical industry. It helps ensure the purity and efficacy of Apixaban, a medication used to treat and prevent blood clots.
Apixaban Impurity 6 is used as a research tool for studying the structure-activity relationship of Apixaban and its analogs. This helps scientists understand the molecular interactions and optimize the drug's therapeutic potential.
Additionally, Apixaban Impurity 6 may be used in the development of new drugs targeting coagulation factor Xa, as understanding the properties of impurities can contribute to the design of more effective and safer medications.

Upstream product

• 67-56-1 methanol 
• 503614-92-4 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 503614-91-3 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 
• 124-41-4 sodium methylate 

Downstream Products

• 1351611-14-7 N-formyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole-[3,4-c]pyridine-3-carboxamide 

Relevant articles and documents

A mechanistic study on the amidation of esters mediated by sodium formamide

Kinetic and computational studies on the amidation of esters with mixtures of formamide and sodium methoxide are described. Rate studies are consistent with a fast deprotonation of formamide followed by two reversible acyl transfers affected by solvent pa

Method for preparing apixaban

The invention discloses a method for preparing apixaban. The method comprises the following steps: 1) subjecting a compound represented by a formula II to a reaction with a compound represented by a formula III in a two-phase system of water and an organic solvent, so as to obtain a compound represented by a formula IV; 2) subjecting the compound represented by the formula IV to a cyclization reaction in the presence of alkali and a phase transfer catalyst, so as to obtain a compound represented by a formula V; and subjecting the compound represented by the formula V to an ammonolysis reaction, thereby obtaining the apixaban represented by a formula I. The method is simple in operation and low in cost and is applicable to large-scale industrial production.