107785-25-1

Basic information

• Product Name: 1-benzyl-4-(phenylsulfonyl)piperazine
• Synonyms: 1-benzyl-4-(phenylsulfonyl)piperazine
• CAS NO: 107785-25-1
• Molecular Formula: C₁₇H₂₀N₂O₂S
• Molecular Weight: 316.4179
• Mol File: 107785-25-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-4-(phenylsulfonyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(phenylsulfonyl)piperazine(107785-25-1)
• EPA Substance Registry System: 1-benzyl-4-(phenylsulfonyl)piperazine(107785-25-1)

Safety Data

• Hazardous Substances Data: 107785-25-1(Hazardous Substances Data)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 98-09-9 benzenesulfonyl chloride 
• 16728-92-0 N-benzyl-N,N-bis(cyanomethyl)amine 
• 57260-70-5 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 2759-28-6 1-phenylmethylpiperazine 

Relevant articles and documents

PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.

Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands

This study presents the synthesis and biological evaluation of a new series of arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as sigma receptor ligands. It was found that a number of halogen substituted sulfonamides display relatively high and low affinities to σ1 and σ2 receptors, respectively. The σ1 affinities and subtype selectivities of four piperidine derivatives were also found to be generally comparable to those of piperazine analogues. Compared to σ1-Rs compounds with n = 0 and 2, those with n = 1 proved to have optimal length of carbon chain by exhibiting higher affinities. Within this series, the 4-benzyl-1-(3-iodobenzylsulfonyl)piperidine sigma ligand was identified with 96-fold σ1/σ2 selectivity ratio (Kiσ1 = 0.96 ± 0.05 nM and K iσ2 = 91.8 ± 8.1 nM).

Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

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