16728-92-0

Usage

Uses

Used in Organic Synthesis:
3-[BENZYL-(2-CYANO-ETHYL)-AMINO]-PROPIONITRILE is used as a building block in organic synthesis for the creation of various complex organic molecules. Its functional groups can be utilized in multiple reaction pathways, contributing to the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-[BENZYL-(2-CYANO-ETHYL)-AMINO]-PROPIONITRILE is used as a starting material or intermediate in the development of new drugs. Its unique structure and reactivity can be leveraged to design and synthesize pharmaceutical agents with potential therapeutic applications.

Upstream product

• 100-44-7 benzyl chloride 
• 628-87-5 iminodiacetonitrile 
• 107-16-4 glycolonitrile 
• 50-00-0 formaldehyd 
• 7677-24-9 trimethylsilyl cyanide 
• 100-46-9 benzylamine 
• 773837-37-9 sodium cyanide 
• 14321-25-6 (N-benzyl-N-methylamino)acetonitrile 

Downstream Products

• 41536-64-5 2-[Benzyl-(N-hydroxycarbamimidoylmethyl)-amino]-N-hydroxy-acetamidine 
• 871893-10-6 N,N-di(carbamoylmethyl)benzylamine 
• 35975-17-8 4-benzyl-piperazine-2,6-dione 
• 107785-25-1 1-benzyl-4-(phenylsulfonyl)piperazine 
• 3987-53-9 N-benzyliminodiacetic acid 
• 2759-28-6 1-phenylmethylpiperazine 
• 13754-41-1 4-benzyl-piperazin-2-one 
• 6175-26-4 dimethyl 2,2′-(benzylazanediyl)diacetate 

Relevant academic research and scientific papers

RuO4-mediated oxidation of tertiary amines. stereoelectronic effects

Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit

RuO4-Mediated oxidation of tertiary amines. Stereoelectronic effects

Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit

Copper-Catalyzed three- Five- or seven-Component coupling reactions: The selective synthesis of cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines based on a strecker-type synthesis

We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)2 could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.

Facile and selective synthesis of propargylic amines and 1,6-diynes: One-pot three-component coupling reactions of alkynylsilanes, aldehydes and amines by a cooperative catalytic system comprised of CuCl and Cu(OTF) 2

Described herein is a three-component coupling reaction of alkynylsilanes, aldehydes and amines by a cooperative catalytic system comprised of CuCl and Cu(OTf)2, leading to the production of a variety of propargyl amine derivatives. This catalytic system was successfully applied to the practical preparation of 1,6-diyne derivatives via twice-performed, domino-type coupling reactions.