107793-72-6

Basic information

• Product Name: IOXILAN (400 MG)
• Synonyms: IOXILAN (400 MG);1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N-(2,3-dihydroxypropyl)-N'-(2-hydroxyethyl)-2,4,6-triiodo-;Ioxitol;Oxilan 300;5-[Acetyl(2,3-dihydroxypropyl)aMino]-N1-(2,3-dihydroxypropyl)-N3-(2-hydroxyethyl)-2,4,6-triiodo-1,3-benzenedicarboxaMide;5-[acetyl(2,3-dihydroxypropyl)amino]-3-N-(2,3-dihydroxypropyl)-1-N-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
• CAS NO: 107793-72-6
• Molecular Formula: C₁₈H₂₄I₃N₃O₈
• Molecular Weight: 791.101
• Product Categories: Amines;Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 107793-72-6.mol

Chemical Properties

• Boiling Point: 827.8ºC at 760 mmHg
• Flash Point: 454.4ºC
• Appearance: /
• Density: 2.205 g/cm³
• Vapor Pressure: 4.95E-29mmHg at 25°C
• Refractive Index: 1.721
• CAS DataBase Reference: IOXILAN (400 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: IOXILAN (400 MG)(107793-72-6)
• EPA Substance Registry System: IOXILAN (400 MG)(107793-72-6)

Safety Data

• Hazardous Substances Data: 107793-72-6(Hazardous Substances Data)

Usage

Uses

Used in Medical Imaging:
IOXILAN (400 MG) is used as a contrast agent for improving the visualization of blood vessels and internal organs during various diagnostic imaging procedures, such as X-ray, CT scans, and angiography. The radiopaque nature of IOXILAN (400 MG) helps in differentiating between healthy and diseased tissues, making it easier for medical professionals to identify and diagnose various conditions.
Used in Pharmaceutical Industry:
IOXILAN (400 MG) is used as an active pharmaceutical ingredient in the development of diagnostic agents for medical imaging. Its formulation under the brand name Oxilan (Guerbet) is specifically designed to enhance the imaging process and provide better diagnostic outcomes.

InChI:InChI=1/C18H24I3N3O8/c1-8(28)24(5-10(30)7-27)16-14(20)11(17(31)22-2-3-25)13(19)12(15(16)21)18(32)23-4-9(29)6-26/h9-10,25-27,29-30H,2-7H2,1H3,(H,22,31)(H,23,32)

Upstream product

• 906483-36-1 5-acetylamino-N-(2,3-dihydroxy-propyl)-N'-(2-hydroxy-ethyl)-2,4,6-triiodo-isophthalamide 
• 96-24-2 3-monochloro-1,2-propanediol 
• 111453-35-1 5-[N-(2,3-diacetoxypropyl)acetamido]-2,4,6-triiodo-N-(2-acetoxyethyl)-N'-(2,3-dihydroxypropyl)isophthalamide 

Downstream Products

• 953818-34-3 di-isopropylidenyl ioxilan 

Relevant articles and documents

Novel method for synthesizing ioxilan

The invention belongs to the technical field of preparation of a non-ionic X-ray contrast agent and discloses a novel method for synthesizing ioxilan. The novel method for synthesizing ioxilan comprises the step of performing reactions such as acetic anhydride protection, ester exchange, iodination and alkylation to obtain ioxilan by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as a raw material. The invention provides an improved ioxilan synthetic method and a process easy for industrialized purification and solvent recrystallization. The invention provides the ioxilan synthesizing method which is more environment-friendly, cheap, high in yield and high in purity by taking 5-amino-N-(2-hydroxyl ethyl)-m-formamide methyl benzoate as the raw material.

PROCESS FOR THE ATOMIZATION OF IOXILAN

The invention relates to a process for the preparation of ioxilan of formula 5-[N- (2,3-dihydroxypropyl)acetamido]-2,4,6-triiodo-N-(2,3-dihydroxypropyl)-N'-(2- hydroxyethyl)isophthalamide by atomization and to the improved product thus obtained. This process makes it possible to avoid a process by crystallization and results in an active principle having an improved solubility.

Non-ionic polyol contrast media from ionic contrast media

Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.