111453-35-1

Upstream product

• 71-23-8 propan-1-ol 
• 111453-26-0 5-{N-(2,3-diacetoxypropyl)acetamido}-2,4,6-triiodo-3-{N-(2-acetoxyethyl)}carbamoyl-benzoyl chloride 
• 616-30-8 3-Amino-1,2-propanediol 

Downstream Products

• 107793-72-6 ioxilan 

Relevant academic research and scientific papers

PROCESS FOR THE ATOMIZATION OF IOXILAN

The invention relates to a process for the preparation of ioxilan of formula 5-[N- (2,3-dihydroxypropyl)acetamido]-2,4,6-triiodo-N-(2,3-dihydroxypropyl)-N'-(2- hydroxyethyl)isophthalamide by atomization and to the improved product thus obtained. This process makes it possible to avoid a process by crystallization and results in an active principle having an improved solubility.

Non-ionic polyol contrast media from ionic contrast media

Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.