108086-37-9

Basic information

• Product Name: 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE
• Synonyms: 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE;2-chloro-N-(2-chloro-5-nitrophenyl)acetamide(SALTDATA: FREE);2-chloro-N-(2-chloro-5-nitro-phenyl)ethanamide;Acetamide,2-chloro-N-(2-chloro-5-nitrophenyl)-
• CAS NO: 108086-37-9
• Molecular Formula: C₈H₆Cl₂N₂O₃
• Molecular Weight: 249.05
• Mol File: 108086-37-9.mol

Chemical Properties

• Boiling Point: 422.3°C at 760 mmHg
• Flash Point: 209.2°C
• Appearance: /
• Density: 1.579g/cm³
• Vapor Pressure: 2.44E-07mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(108086-37-9)
• EPA Substance Registry System: 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(108086-37-9)

Safety Data

• Hazardous Substances Data: 108086-37-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of new compounds with potential therapeutic and pesticidal properties.
Used in Herbicide Development:
In the agricultural sector, 2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE is used as a potential herbicide, leveraging its chemical properties to control or eliminate unwanted plant growth, thereby enhancing crop productivity and quality.
Used in Dye and Pigment Production:
2-CHLORO-N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE is utilized in the production of dyes and pigments due to its chemical structure that imparts color. This application is particularly relevant in industries such as textiles, plastics, and printing inks, where colorants are essential for product differentiation and aesthetics.

InChI:InChI=1/C8H6Cl2N2O3/c9-4-8(13)11-7-3-5(12(14)15)1-2-6(7)10/h1-3H,4H2,(H,11,13)

Upstream product

• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1393710-18-3 (2Z,5Z)-5-benzylidene-2-(2-chloro-5-nitrophenylimino)thiazolidin-4-one 
• 1393484-99-5 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-[(dimethylamino)methylidene]-3-methylthiazolidin-4-one 
• 1393710-32-1 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-[(dimethylamino)methylidene]thiazolidin-4-one 
• 1393710-23-0 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-(thiophen-2-ylmethylidene)thiazolidin-4-one 
• 1393710-22-9 (2Z,5Z)-5-(4-chlorobenzylidene)-2-(2-chloro-5-nitrophenylimino)thiazolidin-4-one 
• 1393710-21-8 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-(4-nitrobenzylidene)thiazolidin-4-one 
• 1393710-20-7 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-(4-methoxybenzylidene)thiazolidin-4-one 
• 1393710-19-4 (2Z,5Z)-2-(2-chloro-5-nitrophenylimino)-5-(4-methylbenzylidene)thiazolidin-4-one 
• 125983-18-8 (2-Chloro-5-nitro-phenylamino)-oxo-dithioacetic acid methyl ester 
• 449760-84-3 4-methyl-7-nitro-3,4-dihydro-1H-quinoxalin-2-one 
• 449760-69-4 2'-chloro-2-dimethylamino-5'-nitroacetanilide 
• 449760-73-0 2'-chloro-5'-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide 
• 449760-70-7 2'-chloro-5'-nitro-2-pyrrolidinoacetanilide 
• 122734-26-3 (2-Chloro-5-nitro-phenylamino)-oxo-dithioacetic acid; compound with triethyl-amine 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.

NOVEL COMPOUNDS

The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N- [3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula(I) as described and defined herein,to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

4-Thiazolidinones in heterocyclic synthesis: Synthesis of novel enaminones, azolopyrimidines and 2-arylimino-5-arylidene-4-thiazolidinones

The 4-thiazolidinones 3a-d were used as a key intermediates for the synthesis of 2-arylimino-5-arylidene-4-thiazolidinones derivatives 7a-p via nucleophilic addition reactions with the arylidene malononitrile. Moreover the 4-thiazolidinones 3a and 3c condensed with the DMF-DMA to form the corresponding enamines 8 and 9 depending on the reaction conditions. Otherwise the 4-thiazolidinone 3b reacts regioselectively with DMF-DMA to afford the enaminones 10 and 11, respectively. The latter reacts with many heterocyclic amines affording polyfunctionally substituted fused pyrimidine derivatives 13-18. The enamine 8b was also reacted with the 3-amino-1,2,4-triazole to afford the acyclic product 19, which could not be further cyclized to the corresponding tricyclic system 20. Moreover the 4-thiazolidinone 3c reacted with the benzenediazonium chloride to afford the arylhydrazones 12. The X-ray single crystal technique was employed in this study for structure elucidation and Z/E potential isomerism configuration determination. The X-ray crystallographic analyses of eight products could be obtained, thus establishing with certainty the structures proposed in this work.

Synthesis of quinoxaline derivatives from substituted acetanilides through intramolecular quaternization reactions

The cyclization of 2-dialkylamino-2′-halogeno- and 2-chloro-2′-(dialkylamino)acetanilides to quinoxaline derivatives has been studied in detail. These reactions proceed, respectively, through intramolecular aromatic nucleophilic or aliphatic nucleophilic

Monoamine Oxidase and Succinate Dehydrogenase Inhibitory and Anticonvulsant Activities of Some 3-(N-Arylcarboxamidomethyl)-4-quinazolones

3-(N-Arylcarboxamidomethyl)-4-quinazolones (IIIa-k), prepared from N-aryl-2-chloroacetamides (IIa-k) and 4-quinazolones (I), possess ALD50 values from 500-1000 mg/kg and found to inhibit rat brain monoamine oxidase (MAO) (30-65percent) and succinate dehydrogenase (SDH) (10-80percent) in vitro at a concentration of 5*10-4 M and provide 30-50percent protection against pentylenetetrazole-induced convulsions in mice.

Activities of 2-carboxanilido 3-hydroxybenzo[b]thiophens against molluscs Biomphalaria

The title compounds are shown to be nearly as active against molluscs as Niclosamide when they are either dihalogenated or monohalogenated and mononitrated on the benzene ring.