108350-39-6

Basic information

• Product Name: 2-Iodo-1-phenyl-1-butanone
• Synonyms: 2-IODO-1-PHENYL-1-BUTANONE;alpha-Iodobutyrophenone;2-iodo-1-phenylbutan-1-one
• CAS NO: 108350-39-6
• Molecular Formula: C₁₀H₁₁IO
• Molecular Weight: 274.1
• Mol File: 108350-39-6.mol

Chemical Properties

• Boiling Point: 302.1°C at 760 mmHg
• Flash Point: 136.5°C
• Appearance: /
• Density: 1.582
• Vapor Pressure: 0.00101mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 2-Iodo-1-phenyl-1-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-1-phenyl-1-butanone(108350-39-6)
• EPA Substance Registry System: 2-Iodo-1-phenyl-1-butanone(108350-39-6)

Safety Data

• Hazardous Substances Data: 108350-39-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Iodo-1-phenyl-1-butanone is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of organic compounds with potential medicinal properties.
Used in Organic Chemistry Research:
As a reagent in organic chemical reactions, 2-Iodo-1-phenyl-1-butanone is employed for the formation of carbon-carbon and carbon-heteroatom bonds. This capability is crucial for advancing research in organic chemistry, enabling the synthesis of complex molecules and the exploration of novel chemical reactions and mechanisms.
Used in Chemical Synthesis:
2-Iodo-1-phenyl-1-butanone is utilized as a versatile building block in the synthesis of various organic compounds, including specialty chemicals, agrochemicals, and other industrial products. Its reactivity and functional group compatibility make it a valuable component in the development of new materials and chemical processes.

InChI:InChI=1/C10H11IO/c1-2-9(11)10(12)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3

Upstream product

• 495-40-9 propiophenone 
• 622-76-4 1-phenyl-1-butyne 
• 98-88-4 benzoyl chloride 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 75-03-6 ethyl iodide 

Downstream Products

• 495-40-9 propiophenone 
• 16183-46-3 2-hydroxy-1-phenylbutan-1-one 

Relevant articles and documents

Mercury(II) Chloride-Iodine: A Useful Reagent for the Direct and Regiospecific Synthesis of α-Iodocarbonyl Compounds

α-Iodoaldehydes and α-iodoketones are obtained by direct iodination of the corresponding carbonyl compounds with mercury(II) chloride-iodine in a regiospecific manner.

Metal catalyst-free direct α-iodination of ketones with molecular iodine

Ketones are directly converted to the corresponding α-iodoketones in good yields with molecular iodine under metal catalyst-free conditions. A significant difference in the reactivities was observed for aliphatic and aromatic ketones; whereas aliphatic ke

Synthesis of α-heterosubstituted ketones through sulfur mediated difunctionalization of internal alkynes

Synthesis of α-heterosubstituted ketones was achieved through sulfur mediated difunctionalization of internal alkynes in one pot. The reaction design involves: phenyl substituted internal alkyne attacking triflic anhydride activated diphenyl sulfoxide to

α,α-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones

A one-pot alkylation–halogenation of ketosulfoxonium ylides in the presence of alkyl halides is described. The method furnishes several gem-difunctionalized haloketones (an alkyl and F, Cl, Br, or I) in good yields. Replacing alkyl halides with a mixture of electrophilic halogen species and various halide anions led to gem-dihalogenated ketones containing a combination of the same or two different halogens. Kinetic isotopic effects as well as reaction kinetic experiments give insight to the mechanism of these reactions.

Efficient microwave induced direct α-halogenation of carbonyl compounds

A novel and direct method for the synthesis of α-halocarbonyl compounds using sequential treatment of carbonyl compounds with [hydroxy(tosyloxy)iodo]benzene followed by magnesium halides under solvent-free microwave irradiation conditions is described.