108446-73-7

Basic information

• Product Name: 3-[3-(4-BROMO-PHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]-ACRYLIC ACID
• Synonyms: (2E)-3-[3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoate; (2E)-3-[3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoic acid
• CAS NO: 108446-73-7
• Molecular Formula: C₁₈H₁₃BrN₂O₂
• Molecular Weight: 368.2046
• Mol File: 108446-73-7.mol

Chemical Properties

• Boiling Point: 555.4°Cat760mmHg
• Flash Point: 289.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.6E-13mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 3-[3-(4-BROMO-PHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]-ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-(4-BROMO-PHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]-ACRYLIC ACID(108446-73-7)
• EPA Substance Registry System: 3-[3-(4-BROMO-PHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]-ACRYLIC ACID(108446-73-7)

Safety Data

• Hazardous Substances Data: 108446-73-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H13BrN2O2/c19-15-9-6-13(7-10-15)18-14(8-11-17(22)23)12-21(20-18)16-4-2-1-3-5-16/h1-12H,(H,22,23)/b11-8+

Upstream product

• 108446-68-0 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid 
• 141-82-2 malonic acid 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 99-90-1 para-bromoacetophenone 
• 59-88-1 phenylhydrazine hydrochloride 
• 10591-75-0 4-bromoacetophenone phenylhydrazone 
• 108446-86-2 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 

Downstream Products

• 1390681-88-5 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-chlorophenyl)acrylamide 
• 1007543-20-5 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-(4-methoxyphenyl)acrylamide 
• 1390681-87-4 3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-N-phenylacrylamide 
• 1390681-89-6 N-(4-bromophenyl)-3-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)acrylamide 
• 108446-80-6 3-(4-bromophenyl)-1-phenylpyrazole-4-propionic acid 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity

In present study, a series of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N- phenylacrylamide derivatives (5a-8d) were designed, synthesized, and evaluated for HDAC inhibition and tumor cell antiproliferation. All of these compounds are reported for the first time,

Microwave-Assisted Synthesis of 3-(4-Pyrazolyl)propenoic Acids

Under microwave activation, pyrazole-4-carboxaldehydes react with malonic acid in the presence of a small amount of pyridine to give 3-(4-pyrazolyl)propenoic acids in high yields.

Functionally substituted 3-heterylpyrazoles: XI. 3-[3-Aryl(heteryl)pyrazol-4-yl]propenoic and propanoic acids

3-Aryl(heteryl)-4-formylpyrazoles by condensation with malonic acid furnish 3-[3-aryl(heteryl)-pyrazol-4-yl]propenoic acids that in the presence of Raney nickel are reduced by hydrazine hydrate to 3-[3-aryl(heteryl)pyrazol-4-yl]propanoic acids. The succes

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.