108784-42-5Relevant articles and documents
A novel benzoyl amide compounds
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Paragraph 0406-0408, (2016/11/21)
The invention relates to the field of medicinal chemistry, in particular to a novel benzamides compound or a salt acceptable in parmacy of the novel benzamides compound, a preparation method of the novel benzamides compound, a pharmaceutical composition containing the novel benzamides compound and an application of the pharmaceutical composition in preparation of antineoplastic drugs.
A 2-amino-thiazole compounds (by machine translation)
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Paragraph 0582-0584, (2016/10/08)
The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)
Synthesis and in vitro evaluation of imidazo[1,2- b ]pyridazines as ligands for β-amyloid plaques
Zeng, Fanxing,Alagille, David,Tamagnan, Gilles D.,Ciliax, Brian J.,Levey, Allan I.,Goodman, Mark M.
body text, p. 80 - 84 (2010/11/05)
A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of Aβ1?40. Binding affinities of these compounds were found to range from 11.0 to >1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2-(4′-Dimethylaminophenyl)-6- (methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K i = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging Aβ plaques.
Cephalosporin derivatives
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, (2008/06/13)
A cephalosporin derivative of the formula I: STR1 in which X is STR2 represents one of C-7 acyl groups known in the cephalosporin art, R3 is hydrogen or methoxy, R4 is hydrogen, optionally substituted alkyl or allyl, and R5 is an aromatic heterocyclic ring system which is linked via carbon, and which contains a quaternized nitrogen atom.
3-Condensed imidazolium-cephem compounds
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, (2008/06/13)
A compound of the formula; STR1 wherein R1 is an amino group which may be protected, R3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S→O, O or CH2, R4 is a hydrogen atom, methoxy
Imidazopyridazines. I Some 3-Alkoxy-6-halogeno-2-phenyl(and 4'-substituted phenyl)inidazopyridazines and 3-Methoxy-2,6-diphenylimidazopyridazine
Barlin, Gordon B.
, p. 1803 - 1809 (2007/10/02)
A series of 3-alkoxy-6-halogeno-2-phenyl(and 4'-substituted phenyl)imidazopyridazines (1) and 3-methoxy-2,6-diphenylimidazopyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O-alkylation of the c