109216-61-7

Basic information

• Product Name: 2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester
• Synonyms: 2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester;methyl 2-methylindazole-3-carboxylate
• CAS NO: 109216-61-7
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.2
• Mol File: 109216-61-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester(109216-61-7)
• EPA Substance Registry System: 2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester(109216-61-7)

Safety Data

• Hazardous Substances Data: 109216-61-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2H-Indazole-3-carboxylic acid, 2-methyl-, methyl ester is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
2H-Indazole-3-carboxylic acid,2-methyl-, methyl ester is also utilized in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products to improve crop protection and yield.
Used in Medicinal Chemistry and Drug Discovery:
2H-Indazole-3-carboxylic acid, 2-methyl-, methyl ester is used as a building block in medicinal chemistry for the preparation of various organic compounds and intermediates. Its pharmacological properties and biological activities make it a valuable tool in drug discovery, aiding researchers in the design and development of novel therapeutic agents.
Used in Organic Chemistry Research:
As a heterocyclic organic compound, 2H-Indazole-3-carboxylic acid, 2-methyl-, methyl ester is employed in organic chemistry research to explore its reactivity, synthesis pathways, and potential applications in the creation of new organic compounds with diverse functionalities.

Upstream product

• 186581-53-3 diazomethane 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 74-88-4 methyl iodide 
• 4838-00-0 2-methyl-2H-indazole 
• 79-22-1 methyl chloroformate 

Downstream Products

• 34252-44-3 2-Methylindazole-3-carboxylic acid 
• 181071-92-1 2-methyl-2H-indazole-3-carbonyl chloride 

Relevant articles and documents

Efficient syntheses of exo-granisetron hydrochloride and other potential impurities present in granisetron hydrochloride, an anti-emetic drug

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS

2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.

Convenient method for the 3-functionalization of isoindazoles

The C-3 position of isoindazoles is readily functionalized by metalation with lithium diisopropylamide followed by reaction with a variety of electrophiles. Copyright Taylor & Francis LLC.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.