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1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methylis a heterocyclic aromatic organic compound with the molecular formula C13H11N. It is a derivative of imidazole, featuring a 4-ethynyl-2-methoxyphenyl and a 4-methyl substituent. This chemical compound has potential applications in medicinal and pharmaceutical research due to its potential biological activities and therapeutic properties.
Used in Pharmaceutical Research:
1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methylis used as a research compound for its potential biological activities and therapeutic properties. It has been studied for its role as a potential inhibitor of enzyme activity and as a modulator of signaling pathways, which could contribute to the development of new drugs and therapies.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methylis used as a starting material or a building block for the synthesis of more complex molecules with potential medicinal applications. Its unique structure and functional groups make it a valuable component in the design and development of new pharmaceutical agents.
Further research and studies are needed to fully understand the properties and potential applications of 1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methyl-. Its exploration in various scientific fields could lead to significant advancements in medicine and healthcare.

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  • 1093980-57-4 Structure
  • Basic information

    1. Product Name: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-
    2. Synonyms: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-;1-(4-ethynyl-2-methoxyphenyl)-4-methyl-1H-imidazole
    3. CAS NO:1093980-57-4
    4. Molecular Formula: C13H12N2O
    5. Molecular Weight: 212.24718
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1093980-57-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(1093980-57-4)
    11. EPA Substance Registry System: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(1093980-57-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1093980-57-4(Hazardous Substances Data)

1093980-57-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1093980-57-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,3,9,8 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1093980-57:
(9*1)+(8*0)+(7*9)+(6*3)+(5*9)+(4*8)+(3*0)+(2*5)+(1*7)=184
184 % 10 = 4
So 1093980-57-4 is a valid CAS Registry Number.

1093980-57-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-Ethynyl-2-methoxyphenyl)-4-methyl-1H-imidazole

1.2 Other means of identification

Product number -
Other names 1-(4-ethynyl-2-methoxy-phenyl)-4-methyl-1H-imidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1093980-57-4 SDS

1093980-57-4Relevant articles and documents

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Fischer, Christian,Zultanski, Susan L.,Zhou, Hua,Methot, Joey L.,Shah, Sanjiv,Hayashi, Ikuo,Hughes, Bethany L.,Moxham, Christopher M.,Bays, Nathan W.,Smotrov, Nadya,Hill, Armetta D.,Pan, Bo-Sheng,Wu, Zhenhua,Moy, Lily Y.,Tanga, Flobert,Kenific, Candia,Cruz, Jonathan C.,Walker, Deborah,Bouthillette, Melanie,Nikov, George N.,Deshmukh, Sujal V.,Jeliazkova-Mecheva, Valentina V.,Diaz, Damaris,Michener, Maria S.,Cook, Jacquelynn J.,Munoz, Benito,Shearman, Mark S.

, p. 3488 - 3494 (2015/08/06)

Abstract Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discovery of novel benzo-fused azepinones. Several benzazepinones were profiled in vivo and found to lower brain Aβ42 levels in Sprague Dawley rats and transgenic APP-YAC mice in a dose-dependent manner after a single oral dose. Compound 34 was further progressed into a pilot study in our cisterna-magna-ported rhesus monkey model, where we observed robust lowering of CSF Aβ42 levels.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability

Fischer, Christian,Zultanski, Susan L.,Zhou, Hua,Methot, Joey L.,Shah, Sanjiv,Nuthall, Hugh,Hughes, Bethany L.,Smotrov, Nadja,Hill, Armetta,Szewczak, Alexander A.,Moxham, Christopher M.,Bays, Nathan,Middleton, Richard E.,Munoz, Benito,Shearman, Mark S.

, p. 3140 - 3146 (2012/06/04)

Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from our aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole 57 was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC 50 in cell-based assays and reduced affinity for the hERG channel.

Triazoles as γ-secretase modulators

Fischer, Christian,Zultanski, Susan L.,Zhou, Hua,Methot, Joey L.,Brown, W. Colby,Mampreian, Dawn M.,Schell, Adam J.,Shah, Sanjiv,Nuthall, Hugh,Hughes, Bethany L.,Smotrov, Nadja,Kenific, Candia M.,Cruz, Jonathan C.,Walker, Deborah,Bouthillette, Melanie,Nikov, George N.,Savage, Dan F.,Jeliazkova-Mecheva, Valentina V.,Diaz, Damaris,Szewczak, Alexander A.,Bays, Nathan,Middleton, Richard E.,Munoz, Benito,Shearman, Mark S.

, p. 4083 - 4087 (2011/08/02)

Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for olefin

TRIAZOLE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS

-

, (2009/01/23)

Compounds of formula I: Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain, in particular Alzheimer's disease.

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