SYNTHESIS OF 3-IMINOXY-(E)-2-METHOXYIMINOPROPIONIC ACID DERIVATIVES AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF ETHYL (E)-3--(E)-2-(METHOXYIMINO)PROPIONATE
Reaction of ethyl α-bromopyruvate, 7, with methoxyamine hydrochloride stereoselectively yielded ethyl 3-bromo-(Z)-2-methoxyiminopropionate, 8.The displacement of the bromine of 8 with the oximes 9 gave ethyl 3-iminoxy-(E)-2-methoxyiminopropionate derivatives 10 which were transformed into the corresponding free acids 4.The configuration around the double bond of the methoxyimino moiety was assigned on the basis of the X-ray crystallographic analysis of the ethyl ester of the acid 4d (10d).
Balsamo, Aldo,Macchia, Bruno,Macchia, Franco,Orlandini, Elisabetta,Salvadori, Cristina,Domiano, Paolo
p. 711 - 716
(2007/10/02)
More Articles about upstream products of 110596-16-2