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T-BUTYL 4-BROMOBUTYRATE, also known as t-butyl 4-bromocrotonate, is an organic compound with the chemical formula C8H13BrO2. It is a potent CB1 receptor antagonist, which plays a significant role in the cannabinoid-1 receptor signaling process. T-BUTYL 4-BROMOBUTYRATE has been found to inhibit feeding behaviors and possesses anti-inflammatory properties, making it a promising candidate for various applications in different industries.

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  • 110661-91-1 Structure
  • Basic information

    1. Product Name: T-BUTYL 4-BROMOBUTYRATE
    2. Synonyms: Butanoic acid, 4-broMo-,1,1-diMethylethyl ester;tert-Butyl 4-bromobutanoate, tech;tert-Butyl4-bromobutanoate95%;4-Bromobutanoic acid tert-butyl ester
    3. CAS NO:110661-91-1
    4. Molecular Formula: C8H15BrO2
    5. Molecular Weight: 223.12
    6. EINECS: N/A
    7. Product Categories: Acids & Esters;Bromine Compounds
    8. Mol File: 110661-91-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 225.9 °C at 760 mmHg
    3. Flash Point: 117.1 °C
    4. Appearance: /
    5. Density: 1.258 g/cm3
    6. Vapor Pressure: 0.0843mmHg at 25°C
    7. Refractive Index: 1.46
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. CAS DataBase Reference: T-BUTYL 4-BROMOBUTYRATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)
    12. EPA Substance Registry System: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)
  • Safety Data

    1. Hazard Codes:  Xi:Irritant;
    2. Statements: 34-36/37/38
    3. Safety Statements: 22-26-36/37/39-45
    4. RIDADR: 1760
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 8
    8. PackingGroup:
    9. Hazardous Substances Data: 110661-91-1(Hazardous Substances Data)

110661-91-1 Usage

Uses

Used in Pharmaceutical Industry:
T-BUTYL 4-BROMOBUTYRATE is used as a pharmaceutical agent for its ability to inhibit the CB1 receptor, which is involved in regulating feeding behaviors. By blocking this receptor, it can help in the development of treatments for obesity and other related conditions.
Used in Research and Development:
T-BUTYL 4-BROMOBUTYRATE is used as a research compound for studying the role of CB1 receptors in various physiological processes. This can lead to a better understanding of the endocannabinoid system and the development of new therapeutic strategies for a range of conditions.
Used in Anti-inflammatory Applications:
T-BUTYL 4-BROMOBUTYRATE is used as an anti-inflammatory agent due to its ability to modulate the immune system and reduce inflammation. This property makes it a potential candidate for the development of treatments for various inflammatory diseases, such as arthritis, asthma, and inflammatory bowel disease.
Used in Drug Delivery Systems:
In the field of drug delivery, T-BUTYL 4-BROMOBUTYRATE can be used as a component in the development of novel drug delivery systems. Its properties as a CB1 receptor antagonist can be leveraged to improve the targeting and efficacy of drugs, particularly in the treatment of obesity and related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 110661-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,6,6 and 1 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 110661-91:
(8*1)+(7*1)+(6*0)+(5*6)+(4*6)+(3*1)+(2*9)+(1*1)=91
91 % 10 = 1
So 110661-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H15BrO2/c1-8(2,3)11-7(10)5-4-6-9/h4-6H2,1-3H3

110661-91-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 4-bromobutanoate

1.2 Other means of identification

Product number -
Other names T-BUTYL 4-BROMOBUTYRATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110661-91-1 SDS

110661-91-1Relevant articles and documents

DNA-templated synthesis of trimethine cyanine dyes: A versatile fluorogenic Reaction for sensing G-quadruplex formation

Meguellati, Kamel,Koripelly, Girish,Ladame, Sylvain

, p. 2738 - 2742 (2010)

(Figure Presented) A healthy glow: Fluorogenic peptide nucleic acids (PNAs) functionalized with indoline derivatives are used to specifically sense G-quadruplex formation. Upon hybridization of both PNAs to the singlestranded flanking arms of quadruplex DNA (see scheme), the synthesis of a trimethine cyanine dye is templated. Dye formation can be detected by the appearance of a characteristic fluorescence signal.

RGD-Porphyrin conjugates: Synthesis and potential application in photodynamic therapy

Chaleix, Vincent,Sol, Vincent,Huang, Yi-Ming,Guilloton, Michel,Granet, Robert,Blais, Jean Claude,Krausz, Pierre

, p. 1486 - 1493 (2003)

We report a convenient solid-phase synthesis and characterisation of a new class of glycosylated porphyrins bearing the RGD tripeptide, designed for photodynamic cancer therapy. The photocytotoxicities of these compounds against the K562 leukemia cell lin

Design and synthesis of triphenylphosphonium-porphyrin@xylan nanoparticles for anticancer photodynamic therapy

Bouramtane, Soukaina,Brégier, Frédérique,Bretin, Ludovic,Chaleix, Vincent,Champavier, Yves,Godard, Jérémy,Léger, David,Launay, Yann,Liagre, Bertrand,Pinon, Aline,Sol, Vincent

, p. 1 - 16 (2021/10/19)

Most photosensitizers (PS) suffer from a lack of water solubility and from a low selectivity toward tumor cells. Delivery systems using nanoparticles make it possible to improve PS water solubility, and also tumor targeting via the enhanced permeability a

Isoindoline compound, and preparation method, pharmaceutical composition and application thereof

-

Paragraph 0475; 0977-0980, (2020/04/17)

The invention relates to a polysubstituted isoindoline compound represented by a general formula (I), and a preparation method, a pharmaceutical composition and an application thereof. Specifically, as a CRL4CRBNE3 ubiquitin ligase regulator with a novel structure, the polysubstituted isoindoline compound provided by the invention has stronger anti-tumor activity and an anti-tumor spectrum, and can be used for preparing medicines for treating diseases related to CRL4CRBNE3 ubiquitin ligase.

Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging

Morozumi, Akihiko,Kamiya, Mako,Uno, Shin-Nosuke,Umezawa, Keitaro,Kojima, Ryosuke,Yoshihara, Toshitada,Tobita, Seiji,Urano, Yasuteru

supporting information, p. 9625 - 9633 (2020/07/25)

Single-molecule localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. We previously introduced a spontaneously blinking rhodamine fluorophore based on an intramolecular spirocyclization reaction for live-cell SMLM under physiological conditions. Here, we report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-infrared (NIR) and green ranges, we succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium.

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Hu, Jiantao,Hu, Biao,Wang, Mingliang,Xu, Fuming,Miao, Bukeyan,Yang, Chao-Yie,Wang, Mi,Liu, Zhaomin,Hayes, Daniel F.,Chinnaswamy, Krishnapriya,Delproposto, James,Stuckey, Jeanne,Wang, Shaomeng

, p. 1420 - 1442 (2019/01/30)

The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degraders base

Control of conformation in α-helix mimicking aromatic oligoamide foldamers through interactions between adjacent side-chains

Arrata, Irene,Grison, Claire M.,Coubrough, Heather M.,Prabhakaran, Panchami,Little, Marc A.,Tomlinson, Darren C.,Webb, Michael E.,Wilson, Andrew J.

, p. 3861 - 3867 (2019/04/26)

The design, synthesis and structural characterization of non-natural oligomers that adopt well-defined conformations, so called foldamers, is a key objective in developing biomimetic 3D functional architectures. For the aromatic oligoamide foldamer family

Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach

Nagaki, Aiichiro,Yamashita, Hiroki,Hirose, Katsuyuki,Tsuchihashi, Yuta,Yoshida, Jun-ichi

supporting information, p. 4027 - 4030 (2019/02/24)

Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.

SUPER-RESOLUTION FLUORESCENT IMAGING PROBE

-

Paragraph 0156; 0157; 0158; 0159, (2018/03/25)

[Problem] To provide a novel fluorescent probe for super-resolution imaging that uses fluorescent light emission characteristics that originate from an intermolecular nucleophilic addition-dissociation equilibrium reaction, and to provide a super-resoluti

Synthesis and Evaluation of a Library of Trifunctional Scaffold-Derived Compounds as Modulators of the Insulin Receptor

Fabre, Benjamin,Pícha, Jan,Vaněk, Václav,Selicharová, Irena,Chrudinová, Martina,Collinsová, Michaela,?áková, Lenka,Budě?ínsky, Milo?,Jirá?ek, Ji?í

supporting information, p. 710 - 722 (2016/12/22)

We designed a combinatorial library of trifunctional scaffold-derived compounds, which were derivatized with 30 different in-house-made azides. The compounds were proposed to mimic insulin receptor (IR)-binding epitopes in the insulin molecule and bind to and activate this receptor. This work has enabled us to test our synthetic and biological methodology and to prove its robustness and reliability for the solid-phase synthesis and testing of combinatorial libraries of the trifunctional scaffold-derived compounds. Our effort resulted in the discovery of two compounds, which were able to weakly induce the autophosphorylation of IR and weakly bind to this receptor at a 0.1 mM concentration. Despite these modest biological results, which well document the well-known difficulty in modulating protein-protein interactions, this study represents a unique example of targeting the IR with a set of nonpeptide compounds that were specifically designed and synthesized for this purpose. We believe that this work can open new perspectives for the development of next-generation insulin mimetics based on the scaffold structure.

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