2623-87-2Relevant academic research and scientific papers
Synthesis and Properties of Novel Surface Active Monomers Based on Derivatives of 4-Hydroxybutyric Acid and 6-Hydroxyhexanoic Acid
Borzenkov, Mykola,Mitina, Natalia,Lobaz, Volodymyr,Hevus, Orest
, p. 133 - 144 (2015)
Novel surface active maleate and methacrylate monomers based on derivatives of ω-hydroxy carboxylic acids have been synthesized. The monomers are comprised of hydrophobic alkyl chains and hydrophilic poly(ethylene glycol), quaternary ammonium, sulfonate and carboxylic fragments. Synthesized monomers sufficiently reduce surface tension at the aqueous solution-air interface. The copolymerization of synthesized monomers with 5-tert-butylperoxy-5-methyl-2-hexene-3-yne monomer and N-vinylpyrrolidone in solvent and emulsion copolymerization of synthesized peroxide containing surface active monomer with styrene have been carried out. The synthesized surface active monomers have been shown to be suitable emulsifiers for obtaining polystyrene colloid dispersions. It has been ascertained that the surface active copolymers obtained can form stable interpolyelectrolyte complexes with oppositely charged polymers.
Boron tribromide as a reagent for anti-Markovnikov addition of HBr to cyclopropanes
Chen, Shuming,Gieuw, Matthew H.,Houk, K. N.,Ke, Zhihai,Yeung, Ying-Yeung
, p. 9426 - 9433 (2020/10/02)
Although radical formation from a trialkylborane is well documented, the analogous reaction mode is unknown for trihaloboranes. We have discovered the generation of bromine radicals from boron tribromide and simple proton sources, such as water ortert-butanol, under open-flask conditions. Cyclopropanes bearing a variety of substituents were hydro- and deuterio-brominated to furnish anti-Markovnikov products in a highly regioselective fashion. NMR mechanistic studies and DFT calculations point to a radical pathway instead of the conventional ionic mechanism expected for BBr3
Synthesis of polysiloxane-based quaternized imidazolium salts with a hydroxy group at the end of alkyl groups
Ichikawa, Tsukasa,Wako, Tsuyoshi,Nemoto, Nobukatsu
, p. 1 - 8 (2015/12/18)
A series of polysiloxane derivatives having quaternized imidazolium moieties with hydroxyalkyl groups ([HPImnOH]Xs) (where n is the number of methylene group and X is counter anion) were prepared by quaternization of poly(3-chloropropylmethylsiloxane) (P1) using 1-(ω-hydroxyalkyl)imidazole derivatives (ImnOHs) and anion-exchange reaction using lithium bis(trifluoromethanesulfonyl)imide. Polysiloxane-based quaternized imidazolium salts having hydroxyalkyl groups with chloride anion ([HPImnOH]Cls) were obtained with high quaternization ratio of approximately 100 mol%. The glass transition temperatures (Tgs) of [HPImnOH]Xs were reduced by introducing a hydroxy group at the end of alkyl groups; however, no significant reduction in Tgs was observed by anion exchange from chloride anion to bis(trifluoromethanesulfonyl)imide one (Tf2N-).
Building blocks for (C15-C3)-modified epothilone D analogs
Valeev,Bikzhanov,Miftakhov
, p. 1511 - 1519 (2015/02/02)
A promising potentially biologically active structure have been designed by isosteric rearrangement of the C15-C3 fragment of epothilone D, and building blocks necessary for its assembly have been synthesized.
Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl- 4(1H)-quinolones
Wube, Abraham A.,Hüfner, Antje,Thomaschitz, Christina,Blunder, Martina,Kollroser, Manfred,Bauer, Rudolf,Bucar, Franz
experimental part, p. 567 - 579 (2011/03/17)
A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13 carbons at position-2 displayed potent inhibitory effects with an MIC value of 1.0 mg/L. In a human diploid embryonic lung cell line, MRC-5 cytotoxicity assay, the alkaloids showed weak to moderate cytotoxic activity. Biological evaluation of these evocarpine analogues on the less pathogenic fast growing strains of mycobacteria showed an interesting antimycobacterial profile and provided significant insight into the structure-activity relationships.
A new one-pot synthetic method for selenium-containing medium-sized α,β-unsaturated cyclic ketones
Sashida, Haruki,Nakayama, Akemi,Kaname, Mamoru
experimental part, p. 3229 - 3236 (2009/05/07)
The reaction of tetrahydroselenopyran-2-one (7) with ethynyllithiums 20a-h, followed by treatment with aqueous 5% H2SO4 successfully led to a two-carbon ring expansion to give the 2-substituted 5,6,7,8-tetrahydroselenocin-4-ones 21a-h in 43-95% yields. Seven- to nine-membered γ-selena-α,β-unsaturated cyclic ketones 22-26 and a 5,6,7,8-tetrahydrotellurocin-4-one 27 were also prepared from the corresponding selenolactones or tellurolactone in a one-pot reaction.
Functional group transformations of diols, cyclic ethers, and lactones using aqueous hydrobromic acid and phase transfer catalyst under microwave irradiation
Kad, Goverdhan L.,Kaur, Irvinder,Bhandari, Monica,Singh, Jasvinder,Kaur, Jasamrit
, p. 339 - 340 (2013/09/06)
Synthesis of bromoalkanols has been achieved from diols, ethers, and lactones using aq HBr (48%) and tetrabutylammonium iodide/bromide as phase transfer catalyst under microwave irradiation. This environmentally benign route provides enhanced yields of products and does away with the use of benzene as compared to existing conventional methods.
Derivatives of quinoline as alpha-2 antagonists
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, (2008/06/13)
A compound of formula I, wherein A, Ra, Rb, R1 to R5, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha-2 antagonist. The compounds I can be used for the treatment of diseases or conditions where alpha-2 antagonists are indicated to be effective.
Interhalogen-Catalyzed Cleavages of Ethers and Esters with Trimethylsilyl Bromide or Chloride
Friedrich, Edwin C.,DeLucca, George
, p. 1678 - 1682 (2007/10/02)
The cleavages of various dialkyl ethers, trimethylsilyl alkyl ethers, and alkyl esters by trimethylsilyl bromide are strongly catalyzed by iodine monobromide.This catalyzed cleavage procedure using iodine monobromide makes possible synthetic applications for trimethylsilyl bromide which were previously ruled out by problems with its low reactivity.Cleavages of benzylic and tertiary alkyl ethers and esters by trimethylsilyl chloride are feasible when catalyzed by iodine monochloride.However, other systems are essentially unreactive toward trimethylsilyl chloride even in the presence of iodine monochloride.
