111041-03-3Relevant articles and documents
Modulators of STING (Stimulator of Interferon Genes)
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Paragraph 0211-0212; 0350; 0352, (2021/04/02)
Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
NEW AND EFFICIENT SYNTHESES OF 4-CARBAMOYLQUINUCLIDINE
Kanai, Takeo,Nomoto, Seiichiro,Komatsu, Yuhki,Ogura,Katsuyuki
, p. 2137 - 2142 (2007/10/02)
Two efficent routes starting from 4-carbamoylpiperidine or 2,2',2''-trichlorotriethylamine were developed for preparing 4-cyanoquinuclidine which was hydrolyzed to give 4-carbamoylquinuclidine, a chemical modifier of cephalosporin antibiotics.
4-cyanopiperidine derivatives
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, (2008/06/13)
A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I): STR1 wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV): wherein X has the same meaning as defined above and Y denotes the same halogen atom as X or another halogen atom. The derivative is useful as intermediate for synthesis of quinuclidine derivative which is in turn useful as intermediate for the production of medicines, chemicals, etc.
