1112208-82-8

Basic information

• Product Name: 2-Fluoro-5-formylphenylboronic acid pinacol ester
• Synonyms: 2-Fluoro-5-formylphenylboronic acid pinacol ester;2-Fluoro-5-forMylbenzeneboronic acid pinacol ester, 96%
• CAS NO: 1112208-82-8
• Molecular Formula: C₁₃H₁₆BFO₃
• Molecular Weight: 268.0890232
• Mol File: 1112208-82-8.mol

Chemical Properties

• Melting Point: 35-40℃
• Boiling Point: 350.0±32.0 °C(Predicted)
• Flash Point: >110°(230°F)
• Appearance: /Solid
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Fluoro-5-formylphenylboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-formylphenylboronic acid pinacol ester(1112208-82-8)
• EPA Substance Registry System: 2-Fluoro-5-formylphenylboronic acid pinacol ester(1112208-82-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 1112208-82-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Fluoro-5-formylphenylboronic acid pinacol ester is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds in organic synthesis. Its unique properties allow for the creation of complex organic compounds, making it a valuable building block in the synthesis of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Fluoro-5-formylphenylboronic acid pinacol ester is used as a key intermediate in the synthesis of various drug molecules. Its ability to form stable bonds with other organic compounds makes it an essential component in the development of new pharmaceuticals with improved therapeutic properties.
Used in Agrochemical Industry:
2-Fluoro-5-formylphenylboronic acid pinacol ester is utilized as a reagent in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in forming stable bonds with other molecules contributes to the development of more effective and environmentally friendly agrochemicals.
Used in Materials Science:
In the field of materials science, 2-Fluoro-5-formylphenylboronic acid pinacol ester is employed as a building block for the synthesis of advanced materials with unique properties. Its ability to form stable bonds with other organic and inorganic compounds allows for the creation of materials with improved performance in various applications, such as electronics, energy storage, and sensing devices.

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 352534-79-3 (2-fluoro-5-formylphenyl)boronic acid 
• 86401-99-2 N-tert-butyl-1-(4-fluorophenyl)methanimine 
• 73183-34-3 bis(pinacol)diborane 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 459-57-4 4-fluorobenzaldehyde 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 

Downstream Products

• 1544673-52-0 2-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione 
• 1544673-68-8 [4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine 
• 1544673-92-8 N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide 
• 1544674-02-3 [5-({N-[2-(cyclohexylamino)-2-oxo-1-phenylethyl]acetamido}methyl)-2-fluorophenyl]boronic acid 
• 1333264-06-4 [4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol 

Relevant articles and documents

DIPHENYL-LIKE COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USES THEREOF

The present invention provides a diphenyl-like compound, and intermediate thereof, a preparation method therefor, a pharmaceutical composition thereof and the uses thereof. According to the invention, the diphenyl-like compound has a significant inhibitory effect on PD-1 and/or PD-L1, and can effectively alleviate or treat related diseases such as cancer.

Formal Ir-Catalyzed Ligand-Enabled Ortho and Meta Borylation of Aromatic Aldehydes via in Situ-Generated Imines

The ligand-enabled development of ortho and meta C-H borylation of aromatic aldehydes is reported. It was envisaged that while ortho borylation could be achieved using tert-butylamine as the traceless protecting/directing group, meta borylation proceeds via an electrostatic interaction and a secondary interaction between the ligand of the catalyst and the substrate. These ligand-substrate electrostatic interactions and secondary B-N interactions provide an unprecedented controlling factor for meta-selective C-H activation/borylation.

Synthesis of boron-containing primary amines

In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters in good to excellent yields. These compounds were further utilized to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation. The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a palladium-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields.