RADICAL ANIONS OF NITROSOIMIDAZOLES: PUTATIVE INTERMEDIATES IN THE MECHANISM OF ACTION OF NITROIMIDAZOLE ANTIBIOTICS
The radical anions of 1-methyl-4-phenyl-5-nitrosoimidazole and 5-phenyl-4-nitrosoimidazole have been detected using temperature resolved e.s.r spectroscopic techniques and are proposed as putative intermediates in the oxidation of thiols to disulphides by the nitrosoimidazoles.
Symons, Martyn C. R.,Bowman, W. Russell,Taylor, Peter F.
p. 3221 - 3224
(2007/10/02)
Nitrosoimidazoles: Highly Bactericidal Analogues of 5-Nitroimidazole Drugs
It is believed that metronidazole and related 5-nitroimidazoles are activated by reduction of the nitro group and that the active species has a nitrogen functionality of intermediate oxidation state.However, the preparation and isolation of the active for
Ehlhardt, William J.,Beaulieu, Bernard B.,Goldman, Peter
p. 323 - 329
(2007/10/02)
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