111469-11-5

Basic information

• Product Name: 1,4-Butanediamine, 2-methyl-, dihydrochloride
• Synonyms: 2-methylbutane-1,4-diamine dihydrochloride
• CAS NO: 111469-11-5
• Molecular Formula: C₅H₁₄N₂*2ClH
• Molecular Weight: 175.09994
• Mol File: 111469-11-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Butanediamine, 2-methyl-, dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Butanediamine, 2-methyl-, dihydrochloride(111469-11-5)
• EPA Substance Registry System: 1,4-Butanediamine, 2-methyl-, dihydrochloride(111469-11-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 111469-11-5(Hazardous Substances Data)

Usage

Molecular Weight

215.18 g/mol

Appearance

Hygroscopic white solid

Solubility

Soluble in water and ethanol

Uses

a. Pharmaceutical intermediate
b. Reagent in organic synthesis
c. Precursor in the synthesis of other organic compounds

Applications

a. Production of various pharmaceutical drugs
b. Development of new drugs and medications in medicinal chemistry

Physical Properties

a. Crystalline structure
b. Hygroscopic nature (absorbs moisture from the air)

Safety Precautions

Handle with care due to potential reactivity with other chemicals and sensitivity to moisture.

Upstream product

• 50561-16-5 pyrrole-3-carboxylic acid hydrazide 
• 40611-85-6 4-Methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 15657-58-6 2-methyl-1,4-butanediamine 
• 77928-77-9 2-methyl-1,4-butanediamide 
• 21307-96-0 methyl 2-methylsuccinate 
• 111469-20-6 3-<(2-tosylhydrazino)carbonyl>pyrrole 
• 7126-57-0 ethyl 4-formylpyrrole-2-carboxylate 
• 35302-95-5 2,4,5-triiodo-3-formylpyrrole 
• 7126-39-8 pyrrole-3-carboxaldehyde 
• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 
• 616-43-3 3-methylpyrrole 
• 111469-06-8 2-methyl-1,4-bis<(benzyloxycarbonyl)amino>butane 

Downstream Products

• 2938-98-9 2-methyl-1,4-butandiol 

Relevant articles and documents

Synthesis of 2-Alkylputrescines from 3-Alkylpyrroles

Acylation of 2-(trichloroacetyl)pyrrole gave the 4-acyl derivatives (from 4-formyl to 4-hexanoyl) in good yields.Alkaline treatment gave corresponding 4-acyl-2-pyrrolecarboxylic acids, were decarboxylated to the 3-acylpyrroles by prior conversion to the 3-acyl-2,4,5-triiodopyrroles followed by hydrogenolysis.The 3-acylpyrroles were reduced by treatment with hydrazine in alkaline medium to the 3-alkylpyrroles.The latter were ring-opened by treatment with hydroxylamine in the presence of bicarbonate to give the dioximes of the corresponding 2-alkylsuccinaldehydes, which were then reduced to the 2-alkylpurescines (1,4-diaminobutanes).Ring-opening of 2,3-dimethylpyrrole followed by reduction of the dioxime gave 1,2-dimethylputrescine; the same sequence gave 1,3-dimethylputrescine from 2,4-dimethylpyrrole, while 3,4-dimethylpyrrole did not ring-open and gave the dioxime of 3,4-dimethylmaleimide.

Preparation and Spectroscopic Studies of Cobalt(III) Complexes Containing Optically Active Seven-membered Chelate Ligands

New cobalt(III) complexes of the types, trans-+, 3+, cis-3+, and 3+, where L denotes a seven-membered chelate diamine ligand, (R)-2-methyl-1,4-butanediamine or meso- and (R or S)-2,5-hexanediamine, have been prepared.The dichloro complexes decompose gradually even in the solid state, and rapidly in methanol.The ammine and ethylenediamine complexes are stable in acidic water, but decompose gradually in neutral water.The absorption and circular dichroism spectra of all the complexes have been recorded in aqueous or acetone solutions.The circular dichroism spectra in the first absorption band region are changed by the addition of sulfate ions, and the variation has been discussed in terms of the structure of isomers and the conformational instability of the seven-membered chelate rings.