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111900-33-5

(1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID, with the chemical formula C7H11NO4, is a biologically significant molecule that functions as an agonist for the metabotropic glutamate receptor 8 (mGluR8). This receptor is a promising target for addressing a range of neurological conditions, such as anxiety, depression, and schizophrenia. (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID's distinctive 1R,3R stereochemistry endows it with specific pharmacological characteristics, rendering it an invaluable asset for exploring the role of mGluR8 and for the potential development of novel therapeutic agents. Furthermore, its structure and attributes make it a beneficial probe for examining the physiological and pathological functions of glutamate receptors within the central nervous system.

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  • 111900-33-5 Structure

  • Basic information

    1. Product Name: (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID
    2. Synonyms: (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID;(1R,3R)-ACPD;(1R,3R)-1-AMINOCYCLOPENTANE-CIS-1,3-DICA RBOXYLIC ACID
    3. CAS NO:111900-33-5
    4. Molecular Formula: C7H11NO4
    5. Molecular Weight: 173.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 111900-33-5.mol

  • Chemical Properties

    1. Melting Point: 277 °C (decomp)
    2. Boiling Point: 352.7±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.452±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.11±0.40(Predicted)
    10. CAS DataBase Reference: (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID(111900-33-5)
    12. EPA Substance Registry System: (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID(111900-33-5)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 20/21/22-36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 111900-33-5(Hazardous Substances Data)

111900-33-5 Usage

Uses

Used in Pharmaceutical Research and Development:
(1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID is utilized as a pharmacological tool for investigating the role of mGluR8 in neurological disorders. Its unique stereochemistry allows for targeted activation of the receptor, providing insights into its function and potential therapeutic applications.
Used in Neurological Disorder Treatment:
In the field of neurology, (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID is employed as a potential therapeutic agent for the treatment of various neurological conditions, including anxiety, depression, and schizophrenia. Its agonistic action on mGluR8 may contribute to the modulation of neurotransmission and amelioration of symptoms associated with these disorders.
Used in Central Nervous System Research:
(1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID serves as a valuable probe in the study of the central nervous system, particularly in understanding the physiological and pathological roles of glutamate receptors. This knowledge can aid in the development of treatments for a variety of neurological and neurodegenerative diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 111900-33-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,9,0 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 111900-33:
(8*1)+(7*1)+(6*1)+(5*9)+(4*0)+(3*0)+(2*3)+(1*3)=75
75 % 10 = 5
So 111900-33-5 is a valid CAS Registry Number.

111900-33-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID

1.2 Other means of identification

Product number -
Other names endo-1,4,4a,8a-tetrahydro-1,4-methano-naphthalene-5,8-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:111900-33-5 SDS

111900-33-5Relevant articles and documents

Carbamate-directed hydroboration: Enantioselective synthesis of the excitatory amino acid 1-aminocyclopentane-1,3-dicarboxylic acid

Hodgson, David M.,Thompson, Alison J.,Wadman, Sjoerd

, p. 3357 - 3358 (2007/10/03)

Carbamate-directed hydroboration (using BH3) of 1-substituted 3- cyclopentenes 2, 6 and 9 and an enantioselective synthesis of the excitatory amine acid 1-aminocyclopentane-1,3-dicarboxylic acid via carbamate-directed asymmetric hydroboration [90% de, 45% ee using (+)-IpcBH2] of cyclopentene 2 are described.

Resolution and regioselective protection of glutamic acid analogues. I- Resolution of diastereomeric α-boroxazolidone derivatives

Acher,Azerad

, p. 731 - 744 (2007/10/02)

Diastereomeric α-boroxazolidone γ-phenylethylamide (or γ-phenylethanolamide) derivatives of 2-, 3- or 4-substituted glutamic acid analogues have been separated by silicagel chromatography, resulting, after deprotection, in a practical method for the resolution of most of these unnatural amino acids.

CHEMOENZYMATIC SYNTHESIS OF CONFORMATIONALLY RIGID GLUTAMIC ACID ANALOGUES

Trigalo, F.,Buisson, D.,Azerad, R.

, p. 6109 - 6112 (2007/10/02)

All stereomers of cyclohexane cyclopentane-derived analogues of glutamic acid have been synthesized from the corresponding 3-keto-cycloalkyl carboxylic acid esters by a combination of microbial steps and standard chemical methods.

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