89253-38-3

Usage

Uses

Used in Neuroscience Research:
(1R,3S)-ACPD is used as a research tool for studying the physiological and pharmacological effects of glutamate receptors. It helps in understanding the role of these receptors in various neurological processes, including learning and memory.
Used in Neurological Process Investigation:
(1R,3S)-ACPD is used as an excitatory agent for neurons to investigate the involvement of glutamate receptors in cognitive functions and memory enhancement.
Used in Therapeutic Research for Neurological Conditions:
(1R,3S)-ACPD is used as a potential therapeutic agent in the study and treatment of conditions such as epilepsy and neurodegenerative diseases, aiming to explore its efficacy in managing or alleviating symptoms associated with these conditions.

Upstream product

• 151-50-8 potassium cyanide 
• 122689-82-1 (1S)-isopropyl 3-oxocyclopentane-1-carboxylate 
• 112896-82-9 (5R,7S)-2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-7-carboxylic acid 
• 98-78-2 3-Oxo-cyclopentanecarboxylic acid 
• 112896-82-9 (5R,7R)-2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-7-carboxylic acid 
• 39026-63-6 trans-1-aminocyclopentane-1,3-dicarboxylic acid 
• 71830-06-3 (-)-(S)-3-oxocyclopentanecarboxylic acid 

Downstream Products

• 111900-33-5 (1R,3R)-ACPD 
• 111900-32-4 (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid 
• 89253-38-3 (1R,3S)-ACPD 
• 111900-31-3 (1S,3S)-ACPD 

Relevant academic research and scientific papers

Carbamate-directed hydroboration: Enantioselective synthesis of the excitatory amino acid 1-aminocyclopentane-1,3-dicarboxylic acid

Carbamate-directed hydroboration (using BH3) of 1-substituted 3- cyclopentenes 2, 6 and 9 and an enantioselective synthesis of the excitatory amine acid 1-aminocyclopentane-1,3-dicarboxylic acid via carbamate-directed asymmetric hydroboration [90% de, 45% ee using (+)-IpcBH2] of cyclopentene 2 are described.

Resolution and regioselective protection of glutamic acid analogues. I- Resolution of diastereomeric α-boroxazolidone derivatives

Diastereomeric α-boroxazolidone γ-phenylethylamide (or γ-phenylethanolamide) derivatives of 2-, 3- or 4-substituted glutamic acid analogues have been separated by silicagel chromatography, resulting, after deprotection, in a practical method for the resolution of most of these unnatural amino acids.

CHEMOENZYMATIC SYNTHESIS OF CONFORMATIONALLY RIGID GLUTAMIC ACID ANALOGUES

All stereomers of cyclohexane cyclopentane-derived analogues of glutamic acid have been synthesized from the corresponding 3-keto-cycloalkyl carboxylic acid esters by a combination of microbial steps and standard chemical methods.