111991-15-2

Basic information

• Product Name: 2-[2-(trifluoromethyl)phenyl]oxirane
• Synonyms: 2-[2-(trifluoromethyl)phenyl]oxirane;UKRORGSYN-BB BBV-026917
• CAS NO: 111991-15-2
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.15
• Mol File: 111991-15-2.mol

Chemical Properties

• Boiling Point: 50 °C(Press: 0.06 Torr)
• Appearance: /
• Density: 1.325±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-[2-(trifluoromethyl)phenyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(trifluoromethyl)phenyl]oxirane(111991-15-2)
• EPA Substance Registry System: 2-[2-(trifluoromethyl)phenyl]oxirane(111991-15-2)

Safety Data

• Hazardous Substances Data: 111991-15-2(Hazardous Substances Data)

Usage

Family

Oxirane

Functional groups

Trifluoromethyl group, Phenyl group

Uses

Building block in organic synthesis, production of pharmaceuticals, agrochemicals, specialty materials

Potential applications

Environmental contaminant, solvent, chemical intermediate

Upstream product

• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 2181-42-2 trimethylsulphonium iodide 
• 395-45-9 o-(trifluoromethyl)styrene 

Downstream Products

• 180534-21-8 2-(2-trifluoromethyl-phenyl)-4-trimethylsilanyl-but-3-yn-1-ol 
• 180534-22-9 2-(2-trifluoromethyl-phenyl)-but-3-yn-1-ol 
• 180534-23-0 tert-butyl-dimethyl-[2-(2-trifluoromethyl-phenyl)-but-3-ynyloxy]-silane 
• 1251070-14-0 (D)-ortho-trifluoromethylstyrene oxide 
• 1435488-47-3 C₉H₆⁽²⁾HF₃O 
• 1435488-48-4 C₉H₆⁽²⁾HF₃O 
• 1435488-49-5 C₁₀H₉F₃O 
• 1435488-50-8 trimethyl[1-(2-trifluoromethylphenyl)epoxyethyl]silane 
• 1435488-51-9 1,1-diphenyl-2-(2-trifluoromethylphenyl)-2,3-epoxy-1-propanol 
• 1435488-52-0 (R)-2-methyl-3-(2-trifluoromethylphenyl)-3,4-epoxy-2-butanol 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 395-45-9 o-(trifluoromethyl)styrene 

Relevant articles and documents

Regio- and chemoselective rearrangement of terminal epoxides into methyl alkyl and aryl ketones

The development of the highly active pincer-type rhodium catalyst 2 for the nucleophilic Meinwald rearrangement of functionalised terminal epoxides into methyl ketones under mild conditions is presented. An excellent regio- and chemoselectivity is obtained for the first time for aryl oxiranes.

Diastereoselective C?H Bond Amination for Disubstituted Pyrrolidines

We report herein the improved diastereoselective synthesis of 2,5-disubstituted pyrrolidines from aliphatic azides. Experimental and theoretical studies of the C?H amination reaction mediated by the iron dipyrrinato complex (AdL)FeCl(OEt2) provided a model for diastereoinduction and allowed for systematic variation of the catalyst to enhance selectivity. Among the iron alkoxide and aryloxide catalysts evaluated, the iron phenoxide complex exhibited superior performance towards the generation of syn 2,5-disubstituted pyrrolidines with high diastereoselectivity.

Three powerful dinuclear metal-organic catalysts for converting CO2 into organic carbonates

Developing efficient catalysts for converting carbon dioxide (CO2) into varied organic carbonates is an important scientific goal. By using the NH2-functionalized tripodal ligand 2-((bis(2-aminoethyl)amino)methyl)phenol (HL), three dinuclear metal-organic complexes [Zn(L)]2·2ClO4 (1), [Cu(L)]2·2ClO4·2H2O (2) and [Cd(L)]2·2ClO4 (3) have been successfully isolated and structurally characterized using single-crystal X-ray diffraction analyses. Considering the dinuclear metal centers and the NH2-functional groups in the structures, 1-3 were investigated as catalysts for converting CO2 into organic carbonates, and the results show that 1-3 exhibit an outstanding ability for converting CO2 into varied organic carbonates at atmospheric pressure (0.1 MPa). The catalytic system also displays a wide substrate scope and high catalytic activity, and the reaction mechanism has been proposed herein.

Enzymatic transformations 63. High-concentration two liquid-liquid phase Aspergillus niger Epoxide hydrolase-catalysed resolution: Application to trifluoromethyl-substituted aromatic epoxides

The aim of this work was to perform different studies allowing us to improve the methodology we had previously described to realise the Aspergillus niger epoxide hydrolase-catalysed resolution of eight trifluoromethyl- substituted styrene oxide derivative