1125828-26-3

Basic information

• Product Name: 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole
• Synonyms: 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole;EOS-61313
• CAS NO: 1125828-26-3
• Molecular Formula: C₁₀H₈BrClN₂
• Molecular Weight: 271.54092
• Mol File: 1125828-26-3.mol

Chemical Properties

• Boiling Point: 344.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.02±0.12(Predicted)
• CAS DataBase Reference: 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole(1125828-26-3)
• EPA Substance Registry System: 1-(2-BroMo-5-chlorophenyl)-3-Methyl-1H-pyrazole(1125828-26-3)

Safety Data

• Hazardous Substances Data: 1125828-26-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(2-Bromo-5-chlorophenyl)-3-methyl-1H-pyrazole is used as a research compound for its potential pharmacological properties, particularly for its ability to act as an enzyme inhibitor. This makes it a candidate for the development of new drugs targeting specific physiological processes.
Used in Organic Chemistry and Chemical Synthesis:
In the field of organic chemistry, 1-(2-Bromo-5-chlorophenyl)-3-methyl-1H-pyrazole may be employed as a reagent or intermediate in the synthesis of other complex organic molecules, contributing to the advancement of chemical research and the creation of novel compounds.

Upstream product

• 1453-58-3 3-Methylpyrazole 
• 1996-29-8 1-bromo-4-chloro-2-fluorobenzene 

Downstream Products

• 1125828-30-9 1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone 
• 1125828-32-1 C₁₂H₈ClF₃N₂O 
• 1033805-26-3 (R)-1-(4-chloro-2-(3-methyl-1H-pyrazole-1-yl)phenyl)-2,2,2-trifluoroethane-1-ol 

Relevant articles and documents

Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors

The central role of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter with important cognitive and behavioral functions is well known. However, 5-HT produced in the brain only accounts for approximately 5% of the total amount of 5-HT generated in the body. At the onset of our work, it appeared that substituted phenylalanine derivatives or related aryl amino acids were required to produce potent inhibitors of TPH1, as significant losses of inhibitory activity were noted in the absence of this structural element. We disclose herein the discovery of a new class of TPH1 inhibitors that significantly lower peripherally 5-HT.

SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS

The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.

METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS

Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.

SOLID FORMS OF (S)-ETHYL 2-AMINO-3-(4-(2-AMINO-6-((R)-1-(4-CHLORO-2-(3-METHYL-1H-PYRAZOL-1-YL)PHENYL)-2,2,2-TRIFLUOROETHOXY)-PYRIMIDIN-4-YL)PHENYL)PROPANOATE AND METHODS OF THEIR USE

Solid forms of (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate and salts thereof are disclosed.