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1453-58-3

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1453-58-3 Usage

Description

3-methyl-pyrazole can be used as an additive in the MTO-catalyzed epoxidation of alkenes.

Reference

Jan-Erling E?ckwall, Modern Oxidation Methods, 2010, ISBN 978-3-527-32320-3

Chemical Properties

clear light yellow liquid

Uses

Its application as nitrification inhibitor of nitrogen fertilizers

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 1453-58-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1453-58:
(6*1)+(5*4)+(4*5)+(3*3)+(2*5)+(1*8)=73
73 % 10 = 3
So 1453-58-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2/c1-4-2-3-5-6-4/h2-3H,1H3,(H,5,6)

1453-58-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L01618)  3-Methyl-1H-pyrazole, 97%   

  • 1453-58-3

  • 5g

  • 254.0CNY

  • Detail
  • Alfa Aesar

  • (L01618)  3-Methyl-1H-pyrazole, 97%   

  • 1453-58-3

  • 25g

  • 601.0CNY

  • Detail
  • Aldrich

  • (M75802)  3-Methylpyrazole  97%

  • 1453-58-3

  • M75802-5G

  • 387.27CNY

  • Detail
  • Aldrich

  • (M75802)  3-Methylpyrazole  97%

  • 1453-58-3

  • M75802-25G

  • 1,359.54CNY

  • Detail

1453-58-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methylpyrazole

1.2 Other means of identification

Product number -
Other names 3-(5)-methylpyrazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1453-58-3 SDS

1453-58-3Relevant articles and documents

New synthesis of 3(5)-methylpyrazole

Levanova,Grabel'Nykh,Volkova,Russavskaya,Klyba,Albanov,Korchevin

, p. 1009 - 1010 (2009)

-

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-CovalentN-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

Armirotti, Andrea,Bandiera, Tiziano,Berti, Francesco,Bertorelli, Rosalia,Bertozzi, Fabio,Bertozzi, Sine Mandrup,Bottegoni, Giovanni,Carbone, Anna,Di Fruscia, Paolo,Fiasella, Annalisa,Giacomina, Francesca,Mengatto, Luisa,Nuzzi, Andrea,Ortega, Jose Antonio,Pagliuca, Chiara,Penna, Ilaria,Pizzirani, Daniela,Ponzano, Stefano,Reggiani, Angelo,Romeo, Elisa,Russo, Debora,Summa, Maria,Tarozzo, Glauco,Giampà, Roberta

, p. 13327 - 13355 (2021/09/20)

Inhibition of intracellularN-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA) from degradation, thus increasing and prolonging its anti-inflammatory and analgesic efficacy at the inflamed site. In the present work, we report the identification of a potent, systemically available, novel class of NAAA inhibitors, featuring a pyrazole azabicyclo[3.2.1]octane structural core. After an initial screening campaign, a careful structure-activity relationship study led to the discovery ofendo-ethoxymethyl-pyrazinyloxy-8-azabicyclo[3.2.1]octane-pyrazole sulfonamide50(ARN19689), which was found to inhibit human NAAA in the low nanomolar range (IC50= 0.042 μM) with a non-covalent mechanism of action. In light of its favorable biochemical, in vitro and in vivo drug-like profile, sulfonamide50could be regarded as a promising pharmacological tool to be further investigated in the field of inflammatory conditions.

A practical and highly efficient reductive dehalogenation of aryl halides using heterogeneous Pd/AlO(OH) nanoparticles and sodium borohydride

Kara, Belguzar Yasemin,Yazici, Melike,Kilbas, Benan,Goksu, Haydar

, p. 5898 - 5902 (2016/09/07)

The reductive dehalogenation of aryl halides was performed by using commercially available aluminium oxy-hydroxide-supported palladium (Pd/AlO(OH)) nanoparticles of about 3?nm size (0.5?wt.?% Pd) with sodium borohydride. The dehalogenated products were obtained with absolute conversion in a mixture of H2O/MeOH (v/v=1/1) under ultrasonic conditions at room temperature. All aryl halides were successfully converted to halogen-free compounds within 1.5–4?h with yields of over 95%. The one-pot catalytic method is presented as a new process for the reductive dehalogenation of halogenated compounds. This method is quite simple, highly efficient and eco-friendly, and has an exceptional recovery rate.

Nitrogen-containing heterocycles from metal β-diketonates

Svistunova,Shapkin,Nikolaeva,Apanasenko

experimental part, p. 756 - 761 (2011/08/06)

Factors determining the reaction of metal β-diketonates with hydrazine, in particular the nature of central metal ion and structure of β-diketonate ligand, are discussed. The possibility for the preparation of other heterocyclic compounds via reaction of metal acetylacetonates with phenylhydrazine, o-phenylenediamine, urea, and thiourea was studied.

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