113118-82-4

Basic information

• Product Name: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE
• Synonyms: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE;5-Chloropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde,5-chloro-(9CI);5-Chloronicotinaldehyde;5-Chloro-3-formylpyridine;5-Chloropyridine-3-carboxaldehyde, 5-Chloro-3-formylpyridine;5-chloropyridin-3-carbaldehyde;5-chloro-3-Pyridinecarboxaldehyde
• CAS NO: 113118-82-4
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• EINECS: 1312995-182-4
• Product Categories: PYRIDINE;pharmacetical;Building Blocks
• Mol File: 113118-82-4.mol

Chemical Properties

• Melting Point: 70-71°C
• Boiling Point: 226.026 °C at 760 mmHg
• Flash Point: 90.498 °C
• Appearance: /
• Density: 1.332 g/cm³
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.15±0.20(Predicted)
• CAS DataBase Reference: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(113118-82-4)
• EPA Substance Registry System: 5-CHLORO-PYRIDINE-3-CARBALDEHYDE(113118-82-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 113118-82-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-PYRIDINE-3-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceuticals. Its reactivity allows for the creation of a wide range of drug molecules, contributing to the development of new medications for treating different diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CHLORO-PYRIDINE-3-CARBALDEHYDE serves as an essential intermediate for the production of pesticides and other agrochemicals. Its incorporation into these products helps enhance crop protection and yield.
Used in Dye and Pigment Production:
5-CHLORO-PYRIDINE-3-CARBALDEHYDE is utilized in the manufacturing process of dyes and pigments due to its ability to form colored compounds. This application is crucial for the textile, paint, and printing industries, where vibrant and stable colors are required.
Used in Organic Chemistry as a Building Block:
As a versatile building block in organic chemistry, 5-CHLORO-PYRIDINE-3-CARBALDEHYDE is employed in numerous chemical reactions to synthesize a variety of organic compounds. Its chlorine and aldehyde groups make it a valuable component in organic synthesis, expanding the scope of possible chemical transformations.
It is important to handle and store 5-CHLORO-PYRIDINE-3-CARBALDEHYDE with care due to its flammable nature and potential hazards, ensuring safety in its applications across different industries.

InChI:InChI=1/C6H4ClNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

• 22620-34-4 (5-chloro-pyridin-3-yl)-methanol 
• 22620-27-5 5-chloronicotinic acid 
• 113118-67-5 3-Chloro-2H-pyridine-1-carboxylic acid phenyl ester 
• 626-60-8 3-Chloropyridine 
• 20825-98-3 5-chloro-nicotinic acid ethyl ester 
• 117830-18-9 5-chloropyridine-3-carbohydrazide 
• 118420-18-1 C₁₃H₁₂ClN₃O₃S 
• 113118-73-3 3-Chloro-5-formyl-2H-pyridine-1-carboxylic acid phenyl ester 
• 85320-79-2 5-chloro-nicotinoyl chloride 

Downstream Products

• 1022156-49-5 2-(5-chloropyridin-3-yl)-8-oxo-9-(2-(trifluoromethyl)phenyl)-8,9-dihydro-7H-purine-6-carboxamide 
• 1410738-76-9 (3'R,4'R,5'R)-6''-chloro-4'-(5-chloropyridin-3-yl)-N-((1r,4R)-4-hydroxycyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide 
• 1208308-08-0 C₂₆H₂₈ClN₇O₂ 
• 118420-36-3 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-chloro-pyridin-3-yl)-acrylamide 

Relevant articles and documents

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula: (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.

HERBICIDALLY AND FUNGICIDALLY ACTIVE 3-HETEROARYL-ISOXAZOLINE-5-CARBOXAMIDES AND 3-HETEROARYL-ISOXAZOLINE-5-THIOAMIDES

Herbicidally and fungicidally active 3-heteroaryl-isoxazoline-5-carboxamides and 3-heteroaryl-isoxazoline-5-thioamides Herbicidally and fungicidally active 3-heteroarylisoxazoline-5-carboxamides and 3-heteroarylisoxazoline-5-thioamides of the formula (I) are described. In this formula (I), R represents radicals such as hydrogen, halogen and organic radicals such as substituted alkyl. A is a bond or a divalent unit. Y is a chalcogen.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.

SYNTHESIS OF SUBSTITUTED 3-PYRIDINECARBOXALDEHYDES

Treatment of 3-substituted 1-(phenoxycarbonyl)-1,2-dihydropyridines with Vilsmeier reagent (POCl3/DMF) gave 3-substituted 5-formyl-1-(phenoxycarbonyl)-1,2-dihydropyridines, which were aromatized with hot sulfur to provide 5-substituted 3-pyridinecarboxaldehydes. The formylation of 4-substituted 1-(phenoxycarbonyl)-1,4-dihydropyridines and subsequent aromatization gave 4-substituted 3-pyridinecarboxaldehydes.