113302-88-8

Basic information

• Product Name: 1H-Indazole, 5-Methyl-7-nitro-
• Synonyms: 1H-Indazole, 5-Methyl-7-nitro-;5-Methyl-7-nitro-1H-indazole
• CAS NO: 113302-88-8
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16008
• EINECS: -0
• Mol File: 113302-88-8.mol

Chemical Properties

• Melting Point: 191-192 °C
• Boiling Point: 397.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.437±0.06 g/cm3(Predicted)
• PKA: 10.25±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole, 5-Methyl-7-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 5-Methyl-7-nitro-(113302-88-8)
• EPA Substance Registry System: 1H-Indazole, 5-Methyl-7-nitro-(113302-88-8)

Safety Data

• Hazardous Substances Data: 113302-88-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indazole, 5-methyl-7-nitrois used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the development of new drugs and medicines with potential therapeutic applications.
Used in Organic Chemistry Research:
1H-Indazole, 5-methyl-7-nitroserves as a valuable tool for researchers in the field of organic chemistry. Its unique structure allows for further functionalization and modification, enabling the synthesis of novel compounds with various biological activities. 1H-Indazole, 5-methyl-7-nitrocan be used to explore new reaction pathways and develop innovative synthetic methods.
Used in Drug Discovery:
The potential applications of 1H-Indazole, 5-methyl-7-nitroin the pharmaceutical industry make it an attractive candidate for drug discovery. Its unique structure and properties can be leveraged to design and develop new drugs with improved efficacy, selectivity, and safety profiles. The nitro group in the molecule can be further modified to explore its impact on the biological activity and pharmaceutical capabilities of the resulting compounds.

Upstream product

• 124-41-4 sodium methylate 
• 113302-74-2 5,5'-dimethyl-7,7'-dinitro-2,2'-biindazole 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 1635-84-3 2,4-Dimethyl-6-nitroanilin 
• 7782-77-6 cis-nitrous acid 
• 66620-31-3 2-hydroxy-5-methyl-3-nitro-benzaldehyde 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 113302-64-0 2-azido-5-methyl-3-nitrobenzaldehyde 
• 113302-69-5 2-azido-5-methyl-3-nitrobenzaldehyde azine 
• 113302-82-2 Toluene-4-sulfonate1-(2-formyl-4-methyl-6-nitro-phenyl)-pyridinium; 
• 95-68-1 2,4-Xylidine 

Downstream Products

• 113302-96-8 7-amino-5-methylindazole 
• 871886-57-6 N-(5-methyl-1(2)H-indazol-7-yl)-acetamide 
• 861326-01-4 (5-methyl-1⁽²⁾H-indazol-7-yl)-(4-nitro-benzyliden)-amine 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

Indole and indazole compounds as an inhibitor of cellular necrosis

The present invention refers to a formula (1) compounds of, pharmaceutically acceptable salts or isomers thereof thereof, and characterized by by containing as active ingredients-associated diseases, cell death and method for the prevention or treatment of relates and compositions. [Formula 1] In formula said R 1, R 2, R 3, R 4, R 5, R 6, A, X, n and m to equal the specification.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

Synthesis and Complexing Properties of Macrocycles Incorporating 2,2'-Biindazolyl Binding Subunits

Substituted 2,2'-biindazoles 4 and 19-23 were prepared in 80-90percent yields by thermal decomposition of o,o'-diazido azines 13-18, which in turn were readily obtained from the corresponding 2-azidobenzaldehydes or 2-azidobenzophenones.The preference of