113565-15-4

Basic information

• Product Name: Podophyllic Acid
• Synonyms: Podophyllic Acid
• CAS NO: 113565-15-4
• Molecular Formula: C₂₂H₂₄O₉
• Molecular Weight: 432.423
• Mol File: 113565-15-4.mol

Chemical Properties

• Boiling Point: 632.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.388±0.06 g/cm3(Predicted)
• PKA: 4.08±0.70(Predicted)
• CAS DataBase Reference: Podophyllic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: Podophyllic Acid(113565-15-4)
• EPA Substance Registry System: Podophyllic Acid(113565-15-4)

Safety Data

• Hazardous Substances Data: 113565-15-4(Hazardous Substances Data)

Upstream product

• 78216-00-9 acetyl-epipicropodophyllotoxin 
• 75101-87-0 dimethyl 1,4-epoxy-1,2,3,4-tetrahydro-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-2,3-trans-naphthalenedicarboxylate 
• 75101-87-0 dimethyl 1,4-epoxy-1,2,3,4-tetrahydro-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-2,3-cis-naphthalenedicarboxylate 
• 76886-74-3 C₂₄H₂₂O₁₀ 
• 75101-88-1 methyl 1,4-epoxy-3-exo-(hydroxymethyl)-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2-endo-carboxylate 
• 74879-25-7 -3,4-methylenedioxybenzaldehyde dimethyl acetal 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 74879-22-4 6-bromobenzo-1,3-dioxole-5-carboxaldehyde dimethyl acetal 
• 120-57-0 piperonal 
• 108763-81-1 3-(2',2'-di-t.butyl-r-4'-(3,4-methylenedioxyphenyl)-2'-sila-1',3'-dioxane-c-5'-yl)-propane-1,2-diol 
• 108763-85-5 ((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-acetaldehyde 
• 99463-56-6 (2S,3S)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid 
• 99463-55-5 C₂₃H₃₈O₆Si₂ 
• 99463-47-5 ((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-acetic acid 

Downstream Products

• 477-47-4 (+/-)-epipodophyllotoxin 
• 477-47-4 (+/-)-isopodophyllotoxin 
• 59123-24-9 (±)-β-apopicropodophyllin 
• 477-47-4 (+/-)-epiisopodophyllotoxin 
• 4375-06-8 epipicropodophyllotoxin 

Related news

Action of Podophyllic Acid (cas 113565-15-4) on malignant tumors—I: Distribution of tritiated Podophyllic Acid (cas 113565-15-4) ethyl hydrazide in subcellular fractions of mouse mammary tumors08/22/2019

The intracellular distribution of radioactivity in mammary tumors has been studied following administration of tritiated podophyllic acid ethyl hydrazide to tumorbearing R III mice. Over 90 per cent of the label is found in the 100,000 g supernatant, two thirds of which is associated with two pr...detailed

Action of Podophyllic Acid (cas 113565-15-4) on malignant tumors—II: Effects of Podophyllic Acid (cas 113565-15-4) ethyl hydrazide on the incorporation of precursors into the nucleic acids of mouse mammary tumors and livers in vivo08/21/2019

Administration of podophyllic acid ethyl hydrazide to mice bearing spontaneous mammary tumors, suppresses the incorporation of radioactive precursors into the nucleic acids of the neoplastic tissue. This suppression was also observed in the case of liver nucleic acids but with exceptions in a nu...detailed

Novel biotransformation process of podophyllotoxin to produce Podophyllic Acid (cas 113565-15-4) and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part II: Process optimization08/20/2019

This work optimized the novel biotransformation process of podophyllotoxin to produce podophyllic acid by Pseudomonas aeruginosa CCTCC AB93066. Firstly, the biotransformation process was significantly affected by medium composition. 5 g/l of yeast extract and 5 g/l of peptone were favorable for ...detailed

Relevant articles and documents

Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans

An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN

A novel approach to (+/-)-epipodophyllotoxin (2c) and hence also to (+/-)-podophyllotoxin (1c) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 17a to the tetralin derivative 30c with mesyl chloride.

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN.

A novel approach to (+/-)-epipodophyllotoxin (2) and hence also (+/-)-podophyllotoxin (1) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 14a to the tetralin derivative 15 with mesyl chloride.