75101-87-0Relevant academic research and scientific papers
Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans
Forsey, Steven P.,Rajapaksa, Dayananda,Taylor, Nicholas J.,Rodrigo, Russell
, p. 4280 - 4290 (2007/10/02)
An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t
A Stereo- and Regiocontrolled Synthesis of Podophyllum Lignans
Rodrigo, Russell
, p. 4538 - 4540 (2007/10/02)
A Diels-Alder adduct of an isobenzofuran (generated in situ) and dimethyl acetylenedicarboxylate is converted by a series of controlled reductions and isomerizations to the lignans deoxy- and isodeoxypodophyllotoxin in seven stages.
