113774-72-4Relevant articles and documents
Synthesis and Pharmacological Evaluation of 5,6-exo-Epoxy-7-oxabicycloheptane Derivatives
Das, Jagabandhu,Vu, Truc,Harris, Don N.,Ogletree, Martin L.
, p. 930 - 935 (2007/10/02)
-7-hept-2-yl>-5-heptenoic acid (31) and -7--7-oxabicyclohept-2-yl>-5-heptenoic acid (37) were found to be selective TxA2 antagonists at the platelet and pulmonary thromboxane receptors.An efficient stereospecific synthesis of these compounds and a series of structural analogues is described.Compounds 31 and 37 both inhibited the bronchoconstriction induced by arachidonic acid in the anesthetized guinea pig.
5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
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, (2008/06/13)
5,6-Epoxy-7-oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula STR1 wherein m is 1 to 5, R is H, lower alkyl, alkali metal or polyhydroxylamine, and R1 is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.