Convergent, kilogram scale synthesis of an Akt kinase inhibitor
The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for which
Grongsaard, Pintipa,Bulger, Paul G.,Wallace, Debra J.,Tan, Lushi,Chen, Qinghao,Dolman, Sarah J.,Nyrop, Jason,Hoerrner, R. Scott,Weisel, Mark,Arredondo, Juan,Itoh, Takahiro,Xie, Chengfu,Wen, Xianghui,Zhao, Dalian,Muzzio, Daniel J.,Bassan, Ephraim M.,Shultz, C. Scott
supporting information; experimental part
p. 1069 - 1081
(2012/08/27)
PROCESS FOR SYNTHESIZING 1,2,4-TRIAZOLES
The present invention relates to a process for production of 1,2,4-triazoles. The process comprises the reaction of a disubstituted amide and a hydrazide in the presence of POCl3.
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Page/Page column 9-10
(2010/11/26)
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