114636-37-2

Basic information

• Product Name: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE
• Synonyms: (S)-(-)-1-BOC-3-ACETAMIDOPYRROLIDINE;(S)-1-BOC-3-ACETYLAMINO PYRROLIDINE;TERT-BUTYL (3S)-3-(ACETYLAMINO)-1-PYRROLIDINECARBOXYLATE;(S)-tert-Butyl 3-acetaMidopyrrolidine-1-carboxylate;tert-Butyl (S)-3-acetamidopyrrolidine-1-carboxylate;tert-butyl (3s)-3-acetamidopyrrolidine-1-carboxylate;(S)-N-Boc-3-acetamidopyrrolidine;(S)-N-Boc-3-acetamidopyrrolidine,99%e.e.
• CAS NO: 114636-37-2
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228.2881
• Mol File: 114636-37-2.mol

Chemical Properties

• Melting Point: 86-90 °C
• Boiling Point: 381.3 °Cat 760 mmHg
• Flash Point: 184.4 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 5.11E-06mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: 2-8°C
• PKA: 15.83±0.20(Predicted)
• CAS DataBase Reference: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE(114636-37-2)
• EPA Substance Registry System: (S)-1-BOC-3-ACETAMIDOPYRROLIDINE(114636-37-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 2
• Hazardous Substances Data: 114636-37-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-BOC-3-ACETAMIDOPYRROLIDINE is used as a key intermediate for the synthesis of a variety of drugs. Its role is pivotal in the development of new pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used as a Building Block in Organic Synthesis:
In the realm of organic synthesis, (S)-1-BOC-3-ACETAMIDOPYRROLIDINE is utilized as a building block for the creation of other chiral compounds. Its presence facilitates the construction of complex molecular structures with specific stereochemistry, which is essential for the biological activity and selectivity of the resulting compounds.
Used in the Control of Reactivity and Stereochemistry:
The BOC protecting group in (S)-1-BOC-3-ACETAMIDOPYRROLIDINE is used to control the reactivity of the nitrogen atom during synthesis processes. This control is vital for maintaining the desired stereochemistry of the final product, ensuring the compound's efficacy and selectivity in biological systems.

InChI:InChI=1/C11H20N2O3/c1-8(14)12-9-5-6-13(7-9)10(15)16-11(2,3)4/h9H,5-7H2,1-4H3,(H,12,14)/t9-/m0/s1

Upstream product

• 108-24-7 acetic anhydride 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 125552-56-9 (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1394316-91-6 (S)-N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide 

Relevant articles and documents

PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV)

The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

NOVEL COMPOUNDS

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R1 is H, C1-6alkyl, - C(A)D, C3-8cycloalkyl, aryl, het, aryl-C1-4alkyl or het-C1-4/sub