114869-95-3 Usage
Uses
Used in Pharmaceutical Research:
a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate is used as a research compound for exploring its potential as a glycosylation donor in the synthesis of complex carbohydrates and glycoconjugates. Its unique structure may facilitate the development of new glycobiology-based therapeutics and diagnostic tools.
Used in Chemical Research:
In the field of chemical research, a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate serves as a substrate for enzymatic reactions. Its structural features can be exploited to study enzyme specificity, catalytic mechanisms, and the development of novel biocatalysts.
Used in Medicinal Chemistry:
a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate is utilized in medicinal chemistry for investigating its potential biological activity. Given its complex structure, it may exhibit interactions with biological targets, such as receptors or enzymes, which could lead to the discovery of new pharmacological agents or probes for biological research.
Used in Drug Development:
a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate is employed in drug development as a lead compound for the design of new pharmaceuticals. Its unique structural elements may offer advantages in terms of selectivity, potency, or pharmacokinetic properties, contributing to the advancement of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 114869-95-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,6 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 114869-95:
(8*1)+(7*1)+(6*4)+(5*8)+(4*6)+(3*9)+(2*9)+(1*5)=153
153 % 10 = 3
So 114869-95-3 is a valid CAS Registry Number.
114869-95-3Relevant articles and documents
PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
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, (2013/02/28)
Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.
Synthesis of heparin partial structures and their binding activities to platelets
Koshida, Shuhei,Suda, Yasuo,Sobel, Michael,Ormsby, Julie,Kusumoto, Shoichi
, p. 3127 - 3132 (2007/10/03)
A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [3H]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-D-glucopyranosyl)- (1→4)-O-(2-O-sulfo-α-L-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets.
SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III
Petitou, Maurice,Duchaussoy, Philippe,Lederman, Isidore,Choay, Jean,Jaquinet, Jean-Claude,et al.
, p. 67 - 76 (2007/10/02)
The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III.It was obtained in a yield much better than that of the previously synthesized pentasaccharide and exhibited the same biological properties.
